Signal peptidase complex subunit 2 (SPCS2)
Homo sapiens — UniProt Q15005
Data last refreshed: (UniProt release unknown)
Key facts
Signal peptidase complex subunit 2 (SPCS2) is a protein from Homo sapiens identified by UniProt accession Q15005, 226 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.
- UniProt accession: Q15005; gene symbol SPCS2.
- Organism: Homo sapiens.
- Length: 226 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, type 2 diabetes mellitus and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Signal peptidase complex subunit 2 |
|---|---|
| UniProt accession | Q15005 |
| Gene | SPCS2 |
| Organism | Homo sapiens |
| Length | 226 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (20)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- type 2 diabetes mellitus · score 0.09
- body height · score 0.06
- polyp of colon · score 0.02
- lean body mass · score 0.02
- sitting height measurement · score 0.02
- fat body mass · score 0.02
- appendicular lean mass · score 0.02
- parathyroid adenoma · score 0.01
- cancer · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q15005-F1 | alphafold | PREDICTED | 64.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q15005.
Amino-acid sequence (226 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPCS2?
The strongest Open Targets associations for SPCS2 are neurodegenerative disease, type 2 diabetes mellitus, body height, polyp of colon and lean body mass.
How long is the SPCS2 protein?
The Homo sapiens SPCS2 protein (UniProt Q15005) is 226 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q15005 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q15005 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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