Sperm surface protein Sp17 (SPA17)
Homo sapiens — UniProt Q15506
Data last refreshed: (UniProt release unknown)
Key facts
Sperm surface protein Sp17 (SPA17) is a protein from Homo sapiens identified by UniProt accession Q15506, 151 residues long. MolForge cross-references it against 0 known binders and 196 disease associations.
- UniProt accession: Q15506; gene symbol SPA17.
- Organism: Homo sapiens.
- Length: 151 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, neoplasm and cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sperm surface protein Sp17 |
|---|---|
| UniProt accession | Q15506 |
| Gene | SPA17 |
| Organism | Homo sapiens |
| Length | 151 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (196)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.22
- neoplasm · score 0.10
- cancer · score 0.08
- familial atrial fibrillation · score 0.07
- Familial short QT syndrome · score 0.07
- Romano-Ward syndrome · score 0.07
- Brugada syndrome · score 0.07
- Arrhythmogenic right ventricular dysplasia · score 0.07
- Familial progressive cardiac conduction defect · score 0.07
- hypertrophic cardiomyopathy · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q15506-F1 | alphafold | PREDICTED | 77.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q15506.
Amino-acid sequence (151 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPA17?
The strongest Open Targets associations for SPA17 are neurodegenerative disease, neoplasm, cancer, familial atrial fibrillation and Familial short QT syndrome.
How long is the SPA17 protein?
The Homo sapiens SPA17 protein (UniProt Q15506) is 151 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q15506 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q15506 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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