SMAD family member 2 (SMAD2)
Homo sapiens — UniProt Q15796
Data last refreshed: (UniProt release unknown)
Key facts
SMAD family member 2 (SMAD2) is a protein from Homo sapiens identified by UniProt accession Q15796, 467 residues long. MolForge cross-references it against 0 known binders and 677 disease associations.
- UniProt accession: Q15796; gene symbol SMAD2.
- Organism: Homo sapiens.
- Length: 467 amino acids.
- Top disease associations (Open Targets): Loeys-Dietz syndrome 6, colorectal adenocarcinoma and Loeys-Dietz syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SMAD family member 2 |
|---|---|
| UniProt accession | Q15796 |
| Gene | SMAD2 |
| Organism | Homo sapiens |
| Length | 467 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (677)
Diseases linked to this target (Open Targets).
- Loeys-Dietz syndrome 6 · score 0.61
- colorectal adenocarcinoma · score 0.55
- Loeys-Dietz syndrome · score 0.51
- cancer · score 0.48
- genetic disorder · score 0.47
- familial thoracic aortic aneurysm and aortic dissection · score 0.42
- eosinophil count · score 0.42
- colon adenocarcinoma · score 0.40
- gastric carcinoma · score 0.38
- congenital heart disease · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q15796-F1 | alphafold | PREDICTED | 77.65 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q15796.
Amino-acid sequence (467 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMAD2?
The strongest Open Targets associations for SMAD2 are Loeys-Dietz syndrome 6, colorectal adenocarcinoma, Loeys-Dietz syndrome, cancer and genetic disorder.
How long is the SMAD2 protein?
The Homo sapiens SMAD2 protein (UniProt Q15796) is 467 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q15796 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q15796 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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