SMAD family member 1 (SMAD1)
Homo sapiens — UniProt Q15797
Data last refreshed: (UniProt release unknown)
Key facts
SMAD family member 1 (SMAD1) is a protein from Homo sapiens identified by UniProt accession Q15797, 465 residues long. MolForge cross-references it against 0 known binders and 75 disease associations.
- UniProt accession: Q15797; gene symbol SMAD1.
- Organism: Homo sapiens.
- Length: 465 amino acids.
- Top disease associations (Open Targets): hemoglobin measurement, mean corpuscular hemoglobin and Red cell distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SMAD family member 1 |
|---|---|
| UniProt accession | Q15797 |
| Gene | SMAD1 |
| Organism | Homo sapiens |
| Length | 465 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (75)
Diseases linked to this target (Open Targets).
- hemoglobin measurement · score 0.42
- mean corpuscular hemoglobin · score 0.39
- Red cell distribution width · score 0.39
- high density lipoprotein cholesterol measurement · score 0.38
- mean corpuscular hemoglobin concentration · score 0.35
- neurodegenerative disease · score 0.34
- hematocrit · score 0.26
- protein measurement · score 0.26
- ovarian cancer · score 0.23
- low grade glioma · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q15797-F1 | alphafold | PREDICTED | 81.18 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q15797.
Amino-acid sequence (465 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMAD1?
The strongest Open Targets associations for SMAD1 are hemoglobin measurement, mean corpuscular hemoglobin, Red cell distribution width, high density lipoprotein cholesterol measurement and mean corpuscular hemoglobin concentration.
How long is the SMAD1 protein?
The Homo sapiens SMAD1 protein (UniProt Q15797) is 465 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q15797 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q15797 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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