About Neuronal acetylcholine receptor subunit alpha-2
Neuronal acetylcholine receptor subunit alpha-2 (CHRNA2) is a protein
from Homo sapiens identified by UniProt accession
Q15822, 529 residues long.
MolForge cross-references it against 0 known binders and
82 disease associations.
Target properties
| Protein name | Neuronal acetylcholine receptor subunit alpha-2 |
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| UniProt accession | Q15822 |
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| Gene | CHRNA2 |
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| Organism | Homo sapiens |
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| Length | 529 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (6)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (82)
Diseases linked to this target (Open Targets).
- autosomal dominant nocturnal frontal lobe epilepsy · score 0.57
- smoking status measurement · score 0.40
- Benign familial neonatal-infantile seizures · score 0.33
- smoking initiation · score 0.32
- Seizure · score 0.31
- protein measurement · score 0.30
- smoking cessation · score 0.27
- cigarettes per day measurement · score 0.24
- leukocyte count · score 0.23
- eosinophil count · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15822-F1 | alphafold | PREDICTED | 77.03 | — |
Amino-acid sequence (529 residues)
MGPSCPVFLS FTKLSLWWLL LTPAGGEEAK RPPPRAPGDP LSSPSPTALP QGGSHTETED RLFKHLFRGY NRWARPVPNT SDVVIVRFGL SIAQLIDVDE KNQMMTTNVW LKQEWSDYKL RWNPTDFGNI TSLRVPSEMI WIPDIVLYNN ADGEFAVTHM TKAHLFSTGT VHWVPPAIYK SSCSIDVTFF PFDQQNCKMK FGSWTYDKAK IDLEQMEQTV DLKDYWESGE WAIVNATGTY NSKKYDCCAE IYPDVTYAFV IRRLPLFYTI NLIIPCLLIS CLTVLVFYLP SDCGEKITLC ISVLLSLTVF LLLITEIIPS TSLVIPLIGE YLLFTMIFVT LSIVITVFVL NVHHRSPSTH TMPHWVRGAL LGCVPRWLLM NRPPPPVELC HPLRLKLSPS YHWLESNVDA EEREVVVEEE DRWACAGHVA PSVGTLCSHG HLHSGASGPK AEALLQEGEL LLSPHMQKAL EGVHYIADHL RSEDADSSVK EDWKYVAMVI DRIFLWLFII VCFLGTIGLF LPPFLAGMI
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