Biperiden

Anticholinergic — NERVOUS SYSTEM

Key facts

Biperiden is an ofm drug in the Anticholinergic class catalogued in DrugCentral. It was first approved by the FDA in 1959. Its mechanism of action is classified as Cholinergic Antagonists. DrugCentral lists 6 molecular targets, including CHRM1, CHRM4 and CHRM3. Recorded indications include Arteriosclerotic Parkinsonism, Extrapyramidal disease, Parkinson's disease and Parkinsonism.

• Approval status: ofm (first approved 1959 by the FDA).
• Drug class: Anticholinergic.
• Mechanism of action: Cholinergic Antagonists.
• Molecular targets: CHRM1, CHRM4, CHRM3 and CHRM5 (6 listed in DrugCentral).
• Indications: Arteriosclerotic Parkinsonism, Extrapyramidal disease, Parkinson's disease, Parkinsonism and Postencephalitic parkinsonism.
• ATC code: N04AA02 (Tertiary amines).
• Molecular formula: C21H29NO; molecular weight 311.47 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (5)

• Arteriosclerotic Parkinsonism
• Extrapyramidal disease
• Parkinson's disease
• Parkinsonism
• Postencephalitic parkinsonism

Contraindications (33)

• Achalasia of esophagus
• Angle-closure glaucoma
• Atony of colon
• Benign prostatic hyperplasia
• Bleeding
• Chronic heart failure
• Chronic obstructive lung disease
• Conduction disorder of the heart
• Disease of liver
• Disorder of autonomic nervous system
• Disorder of coronary artery
• Dysentery
• Dysuria
• Fever
• Gastric ulcer
• Gastroesophageal reflux disease
• Gastrointestinal obstruction
• Hiatal hernia
• Hypertensive disorder
• Kidney disease
• Low blood pressure
• Myasthenia gravis
• Open-angle glaucoma
• Paralytic ileus
• Pseudomembranous enterocolitis
• Retention of urine
• Severe chronic ulcerative colitis
• Shigellosis
• Tardive dyskinesia
• Thyrotoxicosis
• + 3 more

Mechanism & targets

• Mechanism of action (MoA): Cholinergic Antagonists
• Established pharmacologic class: Anticholinergic

Molecular targets (6)

Target	Gene	Action	Activity
Muscarinic acetylcholine receptor M1	CHRM1	antagonist	Kd 9.32
Muscarinic acetylcholine receptor M4	CHRM4	antagonist	Kd 8.62
Muscarinic acetylcholine receptor M3	CHRM3	antagonist	Kd 8.41
Muscarinic acetylcholine receptor M5	CHRM5	unknown	Ki 8.20
Muscarinic acetylcholine receptor M2	CHRM2	antagonist	Kd 8.20
Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	unknown	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1959-09-08	FDA	—	ABBVIE

ATC classification

ATC code	Therapeutic hierarchy
N04AA02	NERVOUS SYSTEM › ANTI-PARKINSON DRUGS › ANTICHOLINERGIC AGENTS › Tertiary amines

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Neuroleptic malignant syndrome	786.6
Extrapyramidal disorder	380.1
Suicide attempt	339.6
Schizophrenia	302.3
Intentional self-injury	275.7
Drug interaction	271.3
Intentional overdose	267.5
Salivary hypersecretion	256.5
Sopor	251.1
Akathisia	246.1
Delusion	224.4
Dyskinesia	205.5

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Biperiden is on its molecule page.

• Molecular formula: C₂₁H₂₉NO
• Molecular weight: 311.47 g/mol
• CAS number: 514-65-8
• InChIKey: YSXKPIUOCJLQIE-UHFFFAOYSA-N
• PubChem CID: 2381

OC(CCN1CCCCC1)(C1CC2CC1C=C2)C1=CC=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Biperiden used for?

DrugCentral lists the following indications for Biperiden: Arteriosclerotic Parkinsonism, Extrapyramidal disease, Parkinson's disease, Parkinsonism and Postencephalitic parkinsonism.

How does Biperiden work?

Biperiden is classified as Cholinergic Antagonists; its molecular targets in DrugCentral include CHRM1 (antagonist), CHRM4 (antagonist), CHRM3 (antagonist) and CHRM5.

When was Biperiden first approved?

Biperiden was first approved by the FDA in 1959.

What drug class does Biperiden belong to?

Biperiden is in the Anticholinergic class.

What is the chemical formula of Biperiden?

Biperiden has the molecular formula C21H29NO and a molecular weight of 311.47 g/mol.

Sources

• DrugCentral drug card 374 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1101 — compound record and bioactivity
• PubChem CID 2381 — chemical identifiers
• DrugBank DB00810 — drug record
• FDA UNII 0FRP6G56LD — substance identity
• DailyMed: FDA labels for Biperiden — current prescribing information (label search)
• UniProt P11229 (CHRM1) — target protein
• UniProt P08173 (CHRM4) — target protein
• UniProt P20309 (CHRM3) — target protein
• UniProt P08912 (CHRM5) — target protein
• UniProt P08172 (CHRM2) — target protein
• UniProt Q15822 (CHRNA2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.