Doxacurium

MUSCULO-SKELETAL SYSTEM

Key facts

Doxacurium is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1991. DrugCentral lists 3 molecular targets, including CHRM2, CHRNA2 and CHRNA1|CHRNB1|CHRND. Recorded indications include General anesthesia, Muscle relaxation, function and Skeletal Muscle Relaxation for Endotracheal Intubation.

• Approval status: ofm (first approved 1991 by the FDA).
• Molecular targets: CHRM2, CHRNA2 and CHRNA1|CHRNB1|CHRND (3 listed in DrugCentral).
• Indications: General anesthesia, Muscle relaxation, function and Skeletal Muscle Relaxation for Endotracheal Intubation.
• ATC code: M03AC07 (Other quaternary ammonium compounds).
• Molecular formula: C56H78N2O16; molecular weight 1035.24 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (3)

• General anesthesia
• Muscle relaxation, function
• Skeletal Muscle Relaxation for Endotracheal Intubation

Contraindications (5)

• Disorder of acid-base balance
• Disorder of electrolytes
• Hepatic Impairment associated with Hepatic Transplant
• Myasthenia gravis
• Renal Impairment associated with Kidney Transplant

Mechanism & targets

Molecular targets (3)

Target	Gene	Action	Activity
Muscarinic acetylcholine receptor M2	CHRM2	unknown	—
Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	unknown	—
Acetylcholine receptor	CHRNA1|CHRNB1|CHRND	antagonist	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1991-03-07	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
M03AC07	MUSCULO-SKELETAL SYSTEM › MUSCLE RELAXANTS › MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS › Other quaternary ammonium compounds

Chemical structure

• Molecular formula: C₅₆H₇₈N₂O₁₆
• Molecular weight: 1035.24 g/mol
• CAS number: 133814-18-3
• InChIKey: GBLRQXKSCRCLBZ-UHFFFAOYSA-N
• PubChem CID: 60169

COC1=CC(CC2C3=C(OC)C(OC)=C(OC)C=C3CC[N+]2(C)CCCOC(=O)CCC(=O)OCCC[N+]2(C)CCC3=CC(OC)=C(OC)C(OC)=C3C2CC2=CC(OC)=C(OC)C(OC)=C2)=CC(OC)=C1OC

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Doxacurium used for?

DrugCentral lists the following indications for Doxacurium: General anesthesia, Muscle relaxation, function and Skeletal Muscle Relaxation for Endotracheal Intubation.

How does Doxacurium work?

Its molecular targets in DrugCentral include CHRM2, CHRNA2 and CHRNA1|CHRNB1|CHRND (antagonist).

When was Doxacurium first approved?

Doxacurium was first approved by the FDA in 1991.

What is the chemical formula of Doxacurium?

Doxacurium has the molecular formula C56H78N2O16 and a molecular weight of 1035.24 g/mol.

Sources

• DrugCentral drug card 2974 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1237099 — compound record and bioactivity
• PubChem CID 60169 — chemical identifiers
• DrugBank DB01135 — drug record
• FDA UNII P40015Y3WW — substance identity
• DailyMed: FDA labels for Doxacurium — current prescribing information (label search)
• UniProt P08172 (CHRM2) — target protein
• UniProt Q15822 (CHRNA2) — target protein

How this page is built: methodology · editorial policy & corrections.