Beta-synuclein (SNCB)
Homo sapiens — UniProt Q16143
Data last refreshed: (UniProt release unknown)
Key facts
Beta-synuclein (SNCB) is a protein from Homo sapiens identified by UniProt accession Q16143, 134 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.
- UniProt accession: Q16143; gene symbol SNCB.
- Organism: Homo sapiens.
- Length: 134 amino acids.
- Top disease associations (Open Targets): Lewy body dementia, neurodegenerative disease and glioblastoma multiforme.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Beta-synuclein |
|---|---|
| UniProt accession | Q16143 |
| Gene | SNCB |
| Organism | Homo sapiens |
| Length | 134 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (61)
Diseases linked to this target (Open Targets).
- Lewy body dementia · score 0.47
- neurodegenerative disease · score 0.46
- glioblastoma multiforme · score 0.05
- ossification of the posterior longitudinal ligament of the spine · score 0.04
- central nervous system cancer · score 0.04
- melorheostosis · score 0.04
- atypical teratoid rhabdoid tumor · score 0.03
- astrocytoma · score 0.03
- ependymoma · score 0.03
- medulloblastoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q16143-F1 | alphafold | PREDICTED | 61.48 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q16143.
Amino-acid sequence (134 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SNCB?
The strongest Open Targets associations for SNCB are Lewy body dementia, neurodegenerative disease, glioblastoma multiforme, ossification of the posterior longitudinal ligament of the spine and central nervous system cancer.
How long is the SNCB protein?
The Homo sapiens SNCB protein (UniProt Q16143) is 134 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q16143 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q16143 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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