Mitogen-activated protein kinase kinase kinase 11 (MAP3K11)
Homo sapiens — UniProt Q16584
Data last refreshed: (UniProt release unknown)
Key facts
Mitogen-activated protein kinase kinase kinase 11 (MAP3K11) is a protein from Homo sapiens identified by UniProt accession Q16584, 847 residues long. MolForge cross-references it against 14 known binders and 206 disease associations.
- UniProt accession: Q16584; gene symbol MAP3K11.
- Organism: Homo sapiens.
- Length: 847 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Parkinson disease and Alzheimer disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitogen-activated protein kinase kinase kinase 11 |
|---|---|
| UniProt accession | Q16584 |
| Gene | MAP3K11 |
| Organism | Homo sapiens |
| Length | 847 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (206)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- Parkinson disease · score 0.30
- Alzheimer disease · score 0.29
- lysosomal storage disease · score 0.29
- multiple sclerosis · score 0.29
- breast adenocarcinoma · score 0.29
- lung adenocarcinoma · score 0.27
- endometrial cancer · score 0.26
- cutaneous melanoma · score 0.18
- mean platelet volume · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q16584-F1 | alphafold | PREDICTED | 63.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q16584.
Amino-acid sequence (847 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MAP3K11?
The strongest Open Targets associations for MAP3K11 are neurodegenerative disease, Parkinson disease, Alzheimer disease, lysosomal storage disease and multiple sclerosis.
How long is the MAP3K11 protein?
The Homo sapiens MAP3K11 protein (UniProt Q16584) is 847 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q16584 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q16584 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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