LON peptidase N-terminal domain and RING finger protein 2 (LONRF2)
Homo sapiens — UniProt Q1L5Z9
Data last refreshed: (UniProt release unknown)
Key facts
LON peptidase N-terminal domain and RING finger protein 2 (LONRF2) is a protein from Homo sapiens identified by UniProt accession Q1L5Z9, 754 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.
- UniProt accession: Q1L5Z9; gene symbol LONRF2.
- Organism: Homo sapiens.
- Length: 754 amino acids.
- Top disease associations (Open Targets): self reported educational attainment, body mass index and mathematical ability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | LON peptidase N-terminal domain and RING finger protein 2 |
|---|---|
| UniProt accession | Q1L5Z9 |
| Gene | LONRF2 |
| Organism | Homo sapiens |
| Length | 754 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (108)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.43
- body mass index · score 0.42
- mathematical ability · score 0.39
- sodium measurement · score 0.31
- Abnormal urine sodium concentration · score 0.30
- coffee consumption · score 0.30
- waist-hip ratio · score 0.28
- smoking initiation · score 0.27
- diet measurement · score 0.26
- serum non-albumin protein measurement · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q1L5Z9-F1 | alphafold | PREDICTED | 78.23 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q1L5Z9.
Amino-acid sequence (754 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LONRF2?
The strongest Open Targets associations for LONRF2 are self reported educational attainment, body mass index, mathematical ability, sodium measurement and Abnormal urine sodium concentration.
How long is the LONRF2 protein?
The Homo sapiens LONRF2 protein (UniProt Q1L5Z9) is 754 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q1L5Z9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q1L5Z9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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