Izumo sperm-egg fusion protein 4 (IZUMO4)
Homo sapiens — UniProt Q1ZYL8
Data last refreshed: (UniProt release unknown)
Key facts
Izumo sperm-egg fusion protein 4 (IZUMO4) is a protein from Homo sapiens identified by UniProt accession Q1ZYL8, 232 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.
- UniProt accession: Q1ZYL8; gene symbol IZUMO4.
- Organism: Homo sapiens.
- Length: 232 amino acids.
- Top disease associations (Open Targets): cutaneous melanoma, lung adenocarcinoma and head and neck squamous cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Izumo sperm-egg fusion protein 4 |
|---|---|
| UniProt accession | Q1ZYL8 |
| Gene | IZUMO4 |
| Organism | Homo sapiens |
| Length | 232 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (12)
Diseases linked to this target (Open Targets).
- cutaneous melanoma · score 0.23
- lung adenocarcinoma · score 0.23
- head and neck squamous cell carcinoma · score 0.13
- adolescent idiopathic scoliosis · score 0.08
- balding measurement · score 0.07
- leukocyte count · score 0.05
- body height · score 0.03
- ulcerative colitis · score 0.01
- juvenile dermatomyositis · score 0.01
- myxosarcoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q1ZYL8-F1 | alphafold | PREDICTED | 81.35 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q1ZYL8.
Amino-acid sequence (232 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IZUMO4?
The strongest Open Targets associations for IZUMO4 are cutaneous melanoma, lung adenocarcinoma, head and neck squamous cell carcinoma, adolescent idiopathic scoliosis and balding measurement.
How long is the IZUMO4 protein?
The Homo sapiens IZUMO4 protein (UniProt Q1ZYL8) is 232 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q1ZYL8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q1ZYL8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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