Zinc finger protein 423 (ZNF423)
Homo sapiens — UniProt Q2M1K9
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein 423 (ZNF423) is a protein from Homo sapiens identified by UniProt accession Q2M1K9, 1284 residues long. MolForge cross-references it against 0 known binders and 378 disease associations.
- UniProt accession: Q2M1K9; gene symbol ZNF423.
- Organism: Homo sapiens.
- Length: 1284 amino acids.
- Top disease associations (Open Targets): Joubert syndrome, BMI-adjusted waist-hip ratio and Joubert syndrome with oculorenal defect.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein 423 |
|---|---|
| UniProt accession | Q2M1K9 |
| Gene | ZNF423 |
| Organism | Homo sapiens |
| Length | 1284 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (378)
Diseases linked to this target (Open Targets).
- Joubert syndrome · score 0.54
- BMI-adjusted waist-hip ratio · score 0.50
- Joubert syndrome with oculorenal defect · score 0.49
- BMI-adjusted waist circumference · score 0.49
- smoking status measurement · score 0.47
- systolic blood pressure · score 0.46
- body height · score 0.46
- neutrophil count · score 0.45
- mean corpuscular volume · score 0.45
- waist-hip ratio · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q2M1K9-F1 | alphafold | PREDICTED | 60.59 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q2M1K9.
Amino-acid sequence (1284 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZNF423?
The strongest Open Targets associations for ZNF423 are Joubert syndrome, BMI-adjusted waist-hip ratio, Joubert syndrome with oculorenal defect, BMI-adjusted waist circumference and smoking status measurement.
How long is the ZNF423 protein?
The Homo sapiens ZNF423 protein (UniProt Q2M1K9) is 1284 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q2M1K9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q2M1K9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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