A-kinase anchor protein SPHKAP (SPHKAP)

Homo sapiens — UniProt Q2M3C7

Gene: SPHKAPHomo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

A-kinase anchor protein SPHKAP (SPHKAP) is a protein from Homo sapiens identified by UniProt accession Q2M3C7, 1700 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.

UniProt accession: Q2M3C7; gene symbol SPHKAP.
Organism: Homo sapiens.
Length: 1700 amino acids.
Top disease associations (Open Targets): body mass index, body fat percentage and self reported educational attainment.
3D structure: AlphaFold model available.

Target properties

Protein name	A-kinase anchor protein SPHKAP
UniProt accession	Q2M3C7
Gene	SPHKAP
Organism	Homo sapiens
Length	1700 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (92)

Diseases linked to this target (Open Targets).

body mass index · score 0.48
body fat percentage · score 0.45
self reported educational attainment · score 0.45
type 2 diabetes mellitus · score 0.44
lean body mass · score 0.42
fat body mass · score 0.42
body weight · score 0.40
schizophrenia · score 0.39
C-reactive protein measurement · score 0.32
intelligence · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q2M3C7-F1	alphafold	PREDICTED	47.05	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q2M3C7.

Amino-acid sequence (1700 residues)

MDGNSLLSVP SNLESSRMYD VLEPQQGRGC GSSGSGPGNS ITACKKVLRS NSLLESTDYW LQNQRMPCQI GFVEDKSENC ASVCFVNLDV NKDECSTEHL QQKLVNVSPD LPKLISSMNV QQPKENEIVV LSGLASGNLQ ADFEVSQCPW LPDICLVQCA RGNRPNSTNC IIFEINKFLI GLELVQERQL HLETNILKLE DDTNCSLSSI EEDFLTASEH LEEESEVDES RNDYENINVS ANVLESKQLK GATQVEWNCN KEKWLYALED KYINKYPTPL IKTERSPENL TKNTALQSLD PSAKPSQWKR EAVGNGRQAT HYYHSEAFKG QMEKSQALYI PKDAYFSMMD KDVPSACAVA EQRSNLNPGD HEDTRNALPP RQDGEVTTGK YATNLAESVL QDAFIRLSQS QSTLPQESAV SVSVGSSLLP SCYSTKDTVV SRSWNELPKI VVVQSPDGSD AAPQPGISSW PEMEVSVETS SILSGENSSR QPQSALEVAL ACAATVIGTI SSPQATERLK MEQVVSNFPP GSSGALQTQA PQGLKEPSIN EYSFPSALCG MTQVASAVAV CGLGEREEVT CSVAPSGSLP PAAEASEAMP PLCGLASMEL GKEAIAKGLL KEAALVLTRP NTYSSIGDFL DSMNRRIMET ASKSQTLCSE NVVRNELAHT LSNVILRHSI DEVHHKNMII DPNDNRHSSE ILDTLMESTN QLLLDVICFT FKKMSHIVRL GECPAVLSKE TIRRRETEPS CQPSDPGASQ AWTKATESSS SSPLSNSHNT SLVINNLVDG MYSKQDKGGV RPGLFKNPTL QSQLSRSHRV PDSSTATTSS KEIYLKGIAG EDTKSPHHSE NECRASSEGQ RSPTVSQSRS GSQEAEESIH PNTQEKYNCA TSRINEVQVN LSLLGDDLLL PAQSTLQTKH PDIYCITDFA EELADTVVSM ATEIAAICLD NSSGKQPWFC AWKRGSEFLM TPNVPCRSLK RKKESQGSGT AVRKHKPPRL SEIKRKTDEH PELKEKLMNR VVDESMNLED VPDSVNLFAN EVAAKIMNLT EFSMVDGMWQ AQGYPRNRLL SGDRWSRLKA SSCESIPEED SEARAYVNSL GLMSTLSQPV SRASSVSKQS SCESITDEFS RFMVNQMENE GRGFELLLDY YAGKNASSIL NSAMQQACRK SDHLSVRPSC PSKQSSTESI TEEFYRYMLR DIERDSRESA SSRRSSQDWT AGLLSPSLRS PVCHRQSSMP DSRSPCSRLT VNVPIKANSL DGFAQNCPQD FLSVQPVSSA SSSGLCKSDS CLYRRGGTDH ITNMLIHETW ASSIEALMRK NKIIVDDAEE ADTEPVSGGS PSQAEKCANR LAASRMCSGP TLLVQESLDC PRKDSVTECK QPPVSSLSKT ASLTNHSPLD SKKETSSCQD PVPINHKRRS LCSREVPLIQ IETDQREACA GEPEPFLSKS SLLEEAEGHS NDKNIPDVVR GGDTAVSACQ IHSDSLDTRD VPEAEASTEA RAPDEAPNPP SSSEESTGSW TQLANEEDNP DDTSSFLQLS ERSMSNGNSS ATSSLGIMDL DIYQESMPSS PMINELVEEK KILKGQSEST EAPASGPPTG TASPQRSLLV INFDLEPECP DAELRATLQW IAASELGIPT IYFKKSQENR IEKFLDVVQL VHRKSWKVGD IFHAVVQYCK MHEEQKDGRL SLFDWLLELG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with SPHKAP?

The strongest Open Targets associations for SPHKAP are body mass index, body fat percentage, self reported educational attainment, type 2 diabetes mellitus and lean body mass.

How long is the SPHKAP protein?

The Homo sapiens SPHKAP protein (UniProt Q2M3C7) is 1700 amino acids long.

Browse: Targets: S · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q2M3C7 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q2M3C7 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

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