Hyaluronidase-4 (HYAL4)
Homo sapiens — UniProt Q2M3T9
Data last refreshed: (UniProt release unknown)
Key facts
Hyaluronidase-4 (HYAL4) is a protein from Homo sapiens identified by UniProt accession Q2M3T9, 481 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q2M3T9; gene symbol HYAL4.
- Organism: Homo sapiens.
- Length: 481 amino acids.
- Top disease associations (Open Targets): mean corpuscular volume, neurodegenerative disease and reticulocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Hyaluronidase-4 |
|---|---|
| UniProt accession | Q2M3T9 |
| Gene | HYAL4 |
| Organism | Homo sapiens |
| Length | 481 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.37
- neurodegenerative disease · score 0.26
- reticulocyte count · score 0.18
- reticulocyte measurement · score 0.16
- platelet count · score 0.15
- mean platelet volume · score 0.15
- platelet crit · score 0.15
- platelet-to-lymphocyte ratio · score 0.15
- mean corpuscular hemoglobin concentration · score 0.10
- HbA1c measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q2M3T9-F1 | alphafold | PREDICTED | 90.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q2M3T9.
Amino-acid sequence (481 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HYAL4?
The strongest Open Targets associations for HYAL4 are mean corpuscular volume, neurodegenerative disease, reticulocyte count, reticulocyte measurement and platelet count.
How long is the HYAL4 protein?
The Homo sapiens HYAL4 protein (UniProt Q2M3T9) is 481 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q2M3T9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q2M3T9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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