Small G protein signaling modulator 1 (SGSM1)
Homo sapiens — UniProt Q2NKQ1
Data last refreshed: (UniProt release unknown)
Key facts
Small G protein signaling modulator 1 (SGSM1) is a protein from Homo sapiens identified by UniProt accession Q2NKQ1, 1148 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.
- UniProt accession: Q2NKQ1; gene symbol SGSM1.
- Organism: Homo sapiens.
- Length: 1148 amino acids.
- Top disease associations (Open Targets): glucose measurement, neurodegenerative disease and insulin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Small G protein signaling modulator 1 |
|---|---|
| UniProt accession | Q2NKQ1 |
| Gene | SGSM1 |
| Organism | Homo sapiens |
| Length | 1148 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (57)
Diseases linked to this target (Open Targets).
- glucose measurement · score 0.38
- neurodegenerative disease · score 0.37
- insulin measurement · score 0.31
- sclerosing cholangitis · score 0.20
- serum gamma-glutamyl transferase measurement · score 0.06
- microcytic anemia with liver iron overload · score 0.05
- Adult-onset autosomal recessive sideroblastic anemia · score 0.05
- 22q11.2 deletion syndrome · score 0.05
- hemochromatosis type 5 · score 0.05
- FTH1-related iron overload · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q2NKQ1-F1 | alphafold | PREDICTED | 65.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q2NKQ1.
Amino-acid sequence (1148 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SGSM1?
The strongest Open Targets associations for SGSM1 are glucose measurement, neurodegenerative disease, insulin measurement, sclerosing cholangitis and serum gamma-glutamyl transferase measurement.
How long is the SGSM1 protein?
The Homo sapiens SGSM1 protein (UniProt Q2NKQ1) is 1148 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q2NKQ1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q2NKQ1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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