Peroxisomal leader peptide-processing protease (TYSND1)
Homo sapiens — UniProt Q2T9J0
Data last refreshed: (UniProt release unknown)
Key facts
Peroxisomal leader peptide-processing protease (TYSND1) is a protein from Homo sapiens identified by UniProt accession Q2T9J0, 566 residues long. MolForge cross-references it against 0 known binders and 55 disease associations.
- UniProt accession: Q2T9J0; gene symbol TYSND1.
- Organism: Homo sapiens.
- Length: 566 amino acids.
- Top disease associations (Open Targets): PHF-tau measurement, azoospermia and male infertility with teratozoospermia due to single gene mutation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Peroxisomal leader peptide-processing protease |
|---|---|
| UniProt accession | Q2T9J0 |
| Gene | TYSND1 |
| Organism | Homo sapiens |
| Length | 566 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (55)
Diseases linked to this target (Open Targets).
- PHF-tau measurement · score 0.20
- azoospermia · score 0.06
- male infertility with teratozoospermia due to single gene mutation · score 0.04
- hemochromatosis type 2A · score 0.04
- spermatogenic failure 42 · score 0.04
- spermatogenic failure 65 · score 0.04
- spermatogenic failure 51 · score 0.04
- spermatogenic failure 72 · score 0.04
- spermatogenic failure 39 · score 0.04
- spermatogenic failure 56 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q2T9J0-F1 | alphafold | PREDICTED | 83.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q2T9J0.
Amino-acid sequence (566 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TYSND1?
The strongest Open Targets associations for TYSND1 are PHF-tau measurement, azoospermia, male infertility with teratozoospermia due to single gene mutation, hemochromatosis type 2A and spermatogenic failure 42.
How long is the TYSND1 protein?
The Homo sapiens TYSND1 protein (UniProt Q2T9J0) is 566 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q2T9J0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q2T9J0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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