Inhibitory synaptic factor 1 (INSYN1)
Homo sapiens — UniProt Q2T9L4
Data last refreshed: (UniProt release unknown)
Key facts
Inhibitory synaptic factor 1 (INSYN1) is a protein from Homo sapiens identified by UniProt accession Q2T9L4, 293 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.
- UniProt accession: Q2T9L4; gene symbol INSYN1.
- Organism: Homo sapiens.
- Length: 293 amino acids.
- Top disease associations (Open Targets): insomnia measurement, smoking status measurement and smoking behaviour measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Inhibitory synaptic factor 1 |
|---|---|
| UniProt accession | Q2T9L4 |
| Gene | INSYN1 |
| Organism | Homo sapiens |
| Length | 293 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (45)
Diseases linked to this target (Open Targets).
- insomnia measurement · score 0.33
- smoking status measurement · score 0.31
- smoking behaviour measurement · score 0.28
- unipolar depression · score 0.26
- smoking initiation · score 0.26
- risk-taking behaviour · score 0.25
- attention deficit hyperactivity disorder · score 0.17
- antisocial behaviour measurement · score 0.17
- substance abuse · score 0.17
- body weight · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q2T9L4-F1 | alphafold | PREDICTED | 61.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q2T9L4.
Amino-acid sequence (293 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with INSYN1?
The strongest Open Targets associations for INSYN1 are insomnia measurement, smoking status measurement, smoking behaviour measurement, unipolar depression and smoking initiation.
How long is the INSYN1 protein?
The Homo sapiens INSYN1 protein (UniProt Q2T9L4) is 293 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q2T9L4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q2T9L4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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