Smoothelin-like protein 2 (SMTNL2)
Homo sapiens — UniProt Q2TAL5
Data last refreshed: (UniProt release unknown)
Key facts
Smoothelin-like protein 2 (SMTNL2) is a protein from Homo sapiens identified by UniProt accession Q2TAL5, 461 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.
- UniProt accession: Q2TAL5; gene symbol SMTNL2.
- Organism: Homo sapiens.
- Length: 461 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, eosinophil count and rheumatoid arthritis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Smoothelin-like protein 2 |
|---|---|
| UniProt accession | Q2TAL5 |
| Gene | SMTNL2 |
| Organism | Homo sapiens |
| Length | 461 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (29)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- eosinophil count · score 0.23
- rheumatoid arthritis · score 0.20
- rheumatoid factor seropositivity measurement · score 0.20
- anti-citrullinated protein antibody seropositivity · score 0.20
- Eczematoid dermatitis · score 0.12
- asthma · score 0.12
- allergic rhinitis · score 0.12
- Nasal Cavity Polyp · score 0.11
- chronic rhinosinusitis · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q2TAL5-F1 | alphafold | PREDICTED | 65.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q2TAL5.
Amino-acid sequence (461 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMTNL2?
The strongest Open Targets associations for SMTNL2 are neurodegenerative disease, eosinophil count, rheumatoid arthritis, rheumatoid factor seropositivity measurement and anti-citrullinated protein antibody seropositivity.
How long is the SMTNL2 protein?
The Homo sapiens SMTNL2 protein (UniProt Q2TAL5) is 461 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q2TAL5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q2TAL5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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