Collagen alpha-1(XXVIII) chain (COL28A1)
Homo sapiens — UniProt Q2UY09
Data last refreshed: (UniProt release unknown)
Key facts
Collagen alpha-1(XXVIII) chain (COL28A1) is a protein from Homo sapiens identified by UniProt accession Q2UY09, 1125 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.
- UniProt accession: Q2UY09; gene symbol COL28A1.
- Organism: Homo sapiens.
- Length: 1125 amino acids.
- Top disease associations (Open Targets): Dupuytren Contracture, diabetic foot and Peyronie disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Collagen alpha-1(XXVIII) chain |
|---|---|
| UniProt accession | Q2UY09 |
| Gene | COL28A1 |
| Organism | Homo sapiens |
| Length | 1125 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (72)
Diseases linked to this target (Open Targets).
- Dupuytren Contracture · score 0.59
- diabetic foot · score 0.55
- Peyronie disease · score 0.55
- skin wound · score 0.46
- Skin ulcer · score 0.46
- Abnormality of connective tissue · score 0.46
- burn · score 0.46
- Edema · score 0.44
- decubitus ulcer · score 0.43
- ulcer disease · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q2UY09-F1 | alphafold | PREDICTED | 60.06 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q2UY09.
Amino-acid sequence (1125 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with COL28A1?
The strongest Open Targets associations for COL28A1 are Dupuytren Contracture, diabetic foot, Peyronie disease, skin wound and Skin ulcer.
How long is the COL28A1 protein?
The Homo sapiens COL28A1 protein (UniProt Q2UY09) is 1125 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q2UY09 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q2UY09 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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