LETM1 domain-containing protein LETM2, mitochondrial (LETM2)
Homo sapiens — UniProt Q2VYF4
Data last refreshed: (UniProt release unknown)
Key facts
LETM1 domain-containing protein LETM2, mitochondrial (LETM2) is a protein from Homo sapiens identified by UniProt accession Q2VYF4, 491 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: Q2VYF4; gene symbol LETM2.
- Organism: Homo sapiens.
- Length: 491 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, appendicular lean mass and lysosomal storage disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | LETM1 domain-containing protein LETM2, mitochondrial |
|---|---|
| UniProt accession | Q2VYF4 |
| Gene | LETM2 |
| Organism | Homo sapiens |
| Length | 491 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- appendicular lean mass · score 0.26
- lysosomal storage disease · score 0.23
- Parkinson disease · score 0.23
- Alzheimer disease · score 0.23
- multiple sclerosis · score 0.23
- Red cell distribution width · score 0.18
- lean body mass · score 0.17
- lymphocyte count · score 0.16
- mean platelet volume · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q2VYF4-F1 | alphafold | PREDICTED | 61.84 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q2VYF4.
Amino-acid sequence (491 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LETM2?
The strongest Open Targets associations for LETM2 are neurodegenerative disease, appendicular lean mass, lysosomal storage disease, Parkinson disease and Alzheimer disease.
How long is the LETM2 protein?
The Homo sapiens LETM2 protein (UniProt Q2VYF4) is 491 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q2VYF4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q2VYF4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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