Beta-defensin 116 (DEFB116)
Homo sapiens — UniProt Q30KQ4
Data last refreshed: (UniProt release unknown)
Key facts
Beta-defensin 116 (DEFB116) is a protein from Homo sapiens identified by UniProt accession Q30KQ4, 102 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.
- UniProt accession: Q30KQ4; gene symbol DEFB116.
- Organism: Homo sapiens.
- Length: 102 amino acids.
- Top disease associations (Open Targets): lung adenocarcinoma, cutaneous melanoma and squamous cell lung carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Beta-defensin 116 |
|---|---|
| UniProt accession | Q30KQ4 |
| Gene | DEFB116 |
| Organism | Homo sapiens |
| Length | 102 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (10)
Diseases linked to this target (Open Targets).
- lung adenocarcinoma · score 0.24
- cutaneous melanoma · score 0.23
- squamous cell lung carcinoma · score 0.17
- head and neck squamous cell carcinoma · score 0.15
- smoking initiation · score 0.09
- smoking behavior · score 0.09
- smoking status measurement · score 0.07
- adolescent idiopathic scoliosis · score 0.07
- gastric carcinoma · score 0.05
- TPE interval measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q30KQ4-F1 | alphafold | PREDICTED | 67.40 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q30KQ4.
Amino-acid sequence (102 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DEFB116?
The strongest Open Targets associations for DEFB116 are lung adenocarcinoma, cutaneous melanoma, squamous cell lung carcinoma, head and neck squamous cell carcinoma and smoking initiation.
How long is the DEFB116 protein?
The Homo sapiens DEFB116 protein (UniProt Q30KQ4) is 102 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q30KQ4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q30KQ4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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