Beta-defensin 116 (DEFB116)

About Beta-defensin 116

Beta-defensin 116 (DEFB116) is a protein from Homo sapiens identified by UniProt accession Q30KQ4, 102 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.

Target properties

Protein name	Beta-defensin 116
UniProt accession	Q30KQ4
Gene	DEFB116
Organism	Homo sapiens
Length	102 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (10)

Diseases linked to this target (Open Targets).

lung adenocarcinoma · score 0.24
cutaneous melanoma · score 0.23
squamous cell lung carcinoma · score 0.17
head and neck squamous cell carcinoma · score 0.15
smoking initiation · score 0.09
smoking behavior · score 0.09
smoking status measurement · score 0.07
adolescent idiopathic scoliosis · score 0.07
gastric carcinoma · score 0.05
TPE interval measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q30KQ4-F1	alphafold	PREDICTED	67.40	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q30KQ4.

Amino-acid sequence (102 residues)

MSVMKPCLMT IAILMILAQK TPGGLFRSHN GKSREPWNPC ELYQGMCRNA CREYEIQYLT CPNDQKCCLK LSVKITSSKN VKEDYDSNSN LSVTNSSSYS HI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards