Beta-defensin 115 (DEFB115)
Homo sapiens — UniProt Q30KQ5
Data last refreshed: (UniProt release unknown)
Key facts
Beta-defensin 115 (DEFB115) is a protein from Homo sapiens identified by UniProt accession Q30KQ5, 88 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.
- UniProt accession: Q30KQ5; gene symbol DEFB115.
- Organism: Homo sapiens.
- Length: 88 amino acids.
- Top disease associations (Open Targets): lung adenocarcinoma, cutaneous melanoma and ovarian cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Beta-defensin 115 |
|---|---|
| UniProt accession | Q30KQ5 |
| Gene | DEFB115 |
| Organism | Homo sapiens |
| Length | 88 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (11)
Diseases linked to this target (Open Targets).
- lung adenocarcinoma · score 0.24
- cutaneous melanoma · score 0.23
- ovarian cancer · score 0.18
- squamous cell lung carcinoma · score 0.17
- head and neck squamous cell carcinoma · score 0.15
- breast adenocarcinoma · score 0.10
- blood protein measurement · score 0.08
- gastric carcinoma · score 0.02
- TPE interval measurement · score 0.02
- Miyoshi myopathy · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q30KQ5-F1 | alphafold | PREDICTED | 74.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q30KQ5.
Amino-acid sequence (88 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DEFB115?
The strongest Open Targets associations for DEFB115 are lung adenocarcinoma, cutaneous melanoma, ovarian cancer, squamous cell lung carcinoma and head and neck squamous cell carcinoma.
How long is the DEFB115 protein?
The Homo sapiens DEFB115 protein (UniProt Q30KQ5) is 88 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q30KQ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q30KQ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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