Beta-defensin 114 (DEFB114)
Homo sapiens — UniProt Q30KQ6
Data last refreshed: (UniProt release unknown)
Key facts
Beta-defensin 114 (DEFB114) is a protein from Homo sapiens identified by UniProt accession Q30KQ6, 69 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.
- UniProt accession: Q30KQ6; gene symbol DEFB114.
- Organism: Homo sapiens.
- Length: 69 amino acids.
- Top disease associations (Open Targets): lung adenocarcinoma, cutaneous melanoma and glucuronate measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Beta-defensin 114 |
|---|---|
| UniProt accession | Q30KQ6 |
| Gene | DEFB114 |
| Organism | Homo sapiens |
| Length | 69 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (24)
Diseases linked to this target (Open Targets).
- lung adenocarcinoma · score 0.24
- cutaneous melanoma · score 0.23
- glucuronate measurement · score 0.22
- glioblastoma multiforme · score 0.20
- ovarian cancer · score 0.18
- squamous cell lung carcinoma · score 0.17
- head and neck squamous cell carcinoma · score 0.15
- breast adenocarcinoma · score 0.10
- cardiovascular disease · score 0.05
- body mass index · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q30KQ6-F1 | alphafold | PREDICTED | 77.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q30KQ6.
Amino-acid sequence (69 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DEFB114?
The strongest Open Targets associations for DEFB114 are lung adenocarcinoma, cutaneous melanoma, glucuronate measurement, glioblastoma multiforme and ovarian cancer.
How long is the DEFB114 protein?
The Homo sapiens DEFB114 protein (UniProt Q30KQ6) is 69 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q30KQ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q30KQ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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