Beta-defensin 113 (DEFB113)
Homo sapiens — UniProt Q30KQ7
Data last refreshed: (UniProt release unknown)
Key facts
Beta-defensin 113 (DEFB113) is a protein from Homo sapiens identified by UniProt accession Q30KQ7, 82 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.
- UniProt accession: Q30KQ7; gene symbol DEFB113.
- Organism: Homo sapiens.
- Length: 82 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lung adenocarcinoma and cutaneous melanoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Beta-defensin 113 |
|---|---|
| UniProt accession | Q30KQ7 |
| Gene | DEFB113 |
| Organism | Homo sapiens |
| Length | 82 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (11)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- lung adenocarcinoma · score 0.24
- cutaneous melanoma · score 0.23
- gastric adenocarcinoma · score 0.14
- breast adenocarcinoma · score 0.10
- spinal cord disease · score 0.05
- body mass index · score 0.05
- cardiovascular disease · score 0.05
- glucuronate measurement · score 0.03
- PHF-tau measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q30KQ7-F1 | alphafold | PREDICTED | 75.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q30KQ7.
Amino-acid sequence (82 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DEFB113?
The strongest Open Targets associations for DEFB113 are neurodegenerative disease, lung adenocarcinoma, cutaneous melanoma, gastric adenocarcinoma and breast adenocarcinoma.
How long is the DEFB113 protein?
The Homo sapiens DEFB113 protein (UniProt Q30KQ7) is 82 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q30KQ7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q30KQ7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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