Small integral membrane protein 21 (SMIM21)
Homo sapiens — UniProt Q3B7S5
Data last refreshed: (UniProt release unknown)
Key facts
Small integral membrane protein 21 (SMIM21) is a protein from Homo sapiens identified by UniProt accession Q3B7S5, 101 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.
- UniProt accession: Q3B7S5; gene symbol SMIM21.
- Organism: Homo sapiens.
- Length: 101 amino acids.
- Top disease associations (Open Targets): language measurement, functional brain measurement and systolic blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Small integral membrane protein 21 |
|---|---|
| UniProt accession | Q3B7S5 |
| Gene | SMIM21 |
| Organism | Homo sapiens |
| Length | 101 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (20)
Diseases linked to this target (Open Targets).
- language measurement · score 0.28
- functional brain measurement · score 0.28
- systolic blood pressure · score 0.27
- chronotype measurement · score 0.26
- motion sickness · score 0.26
- serum gamma-glutamyl transferase measurement · score 0.23
- prostate carcinoma · score 0.20
- mean platelet volume · score 0.20
- platelet count · score 0.17
- colorectal cancer · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q3B7S5-F1 | alphafold | PREDICTED | 69.22 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q3B7S5.
Amino-acid sequence (101 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMIM21?
The strongest Open Targets associations for SMIM21 are language measurement, functional brain measurement, systolic blood pressure, chronotype measurement and motion sickness.
How long is the SMIM21 protein?
The Homo sapiens SMIM21 protein (UniProt Q3B7S5) is 101 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q3B7S5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q3B7S5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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