ATP-dependent chromatin remodeler CHD9 (CHD9)
Homo sapiens — UniProt Q3L8U1
Data last refreshed: (UniProt release unknown)
Key facts
ATP-dependent chromatin remodeler CHD9 (CHD9) is a protein from Homo sapiens identified by UniProt accession Q3L8U1, 2897 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.
- UniProt accession: Q3L8U1; gene symbol CHD9.
- Organism: Homo sapiens.
- Length: 2897 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, mean platelet volume and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ATP-dependent chromatin remodeler CHD9 |
|---|---|
| UniProt accession | Q3L8U1 |
| Gene | CHD9 |
| Organism | Homo sapiens |
| Length | 2897 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (72)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- mean platelet volume · score 0.42
- platelet count · score 0.40
- neutrophil count · score 0.39
- fibrinogen measurement · score 0.35
- leukocyte count · score 0.35
- monocyte percentage of leukocytes · score 0.33
- serum gamma-glutamyl transferase measurement · score 0.32
- apolipoprotein A 1 measurement · score 0.32
- glomerular filtration rate · score 0.31
3D Structure (9)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q3L8U1-F4 | alphafold | PREDICTED | 73.27 | — |
| AF-Q3L8U1-F5 | alphafold | PREDICTED | 68.18 | — |
| AF-Q3L8U1-F3 | alphafold | PREDICTED | 67.06 | — |
| AF-Q3L8U1-F6 | alphafold | PREDICTED | 62.49 | — |
| AF-Q3L8U1-F2 | alphafold | PREDICTED | 61.89 | — |
| AF-Q3L8U1-F7 | alphafold | PREDICTED | 60.33 | — |
| AF-Q3L8U1-F1 | alphafold | PREDICTED | 58.87 | — |
| AF-Q3L8U1-F8 | alphafold | PREDICTED | 57.80 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q3L8U1.
Amino-acid sequence (2897 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CHD9?
The strongest Open Targets associations for CHD9 are neurodegenerative disease, mean platelet volume, platelet count, neutrophil count and fibrinogen measurement.
How long is the CHD9 protein?
The Homo sapiens CHD9 protein (UniProt Q3L8U1) is 2897 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q3L8U1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q3L8U1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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