Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase (ADPRM)
Homo sapiens — UniProt Q3LIE5
Data last refreshed: (UniProt release unknown)
Key facts
Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase (ADPRM) is a protein from Homo sapiens identified by UniProt accession Q3LIE5, 342 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.
- UniProt accession: Q3LIE5; gene symbol ADPRM.
- Organism: Homo sapiens.
- Length: 342 amino acids.
- Top disease associations (Open Targets): leigh syndrome due to mitochondrial complex iv deficiency, mitochondrial complex IV deficiency, nuclear type 22 and Leigh syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase |
|---|---|
| UniProt accession | Q3LIE5 |
| Gene | ADPRM |
| Organism | Homo sapiens |
| Length | 342 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (10)
Diseases linked to this target (Open Targets).
- leigh syndrome due to mitochondrial complex iv deficiency · score 0.15
- mitochondrial complex IV deficiency, nuclear type 22 · score 0.15
- Leigh syndrome · score 0.15
- musculoskeletal system disease · score 0.04
- attention deficit hyperactivity disorder · score 0.03
- X-linked intellectual disability-psychosis-macroorchidism syndrome · score 0.03
- breast cancer · score 0.00
- neoplasm · score 0.00
- invasive breast ductal carcinoma · score 0.00
- acute myeloid leukemia · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q3LIE5-F1 | alphafold | PREDICTED | 94.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q3LIE5.
Amino-acid sequence (342 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ADPRM?
The strongest Open Targets associations for ADPRM are leigh syndrome due to mitochondrial complex iv deficiency, mitochondrial complex IV deficiency, nuclear type 22, Leigh syndrome, musculoskeletal system disease and attention deficit hyperactivity disorder.
How long is the ADPRM protein?
The Homo sapiens ADPRM protein (UniProt Q3LIE5) is 342 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q3LIE5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q3LIE5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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