Triokinase/FMN cyclase (TKFC)
Homo sapiens — UniProt Q3LXA3
Data last refreshed: (UniProt release unknown)
Key facts
Triokinase/FMN cyclase (TKFC) is a protein from Homo sapiens identified by UniProt accession Q3LXA3, 575 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.
- UniProt accession: Q3LXA3; gene symbol TKFC.
- Organism: Homo sapiens.
- Length: 575 amino acids.
- Top disease associations (Open Targets): triokinase and FMN cyclase deficiency syndrome, Congenital cataract - hypertrophic cardiomyopathy - mitochondrial myopathy and COVID-19.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Triokinase/FMN cyclase |
|---|---|
| UniProt accession | Q3LXA3 |
| Gene | TKFC |
| Organism | Homo sapiens |
| Length | 575 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (41)
Diseases linked to this target (Open Targets).
- triokinase and FMN cyclase deficiency syndrome · score 0.64
- Congenital cataract - hypertrophic cardiomyopathy - mitochondrial myopathy · score 0.37
- COVID-19 · score 0.37
- inborn errors of metabolism · score 0.33
- skin pigmentation · score 0.20
- refractive error measurement · score 0.16
- body height · score 0.05
- hypertension · score 0.04
- Autosomal recessive malignant osteopetrosis · score 0.04
- blood pressure · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q3LXA3-F1 | alphafold | PREDICTED | 95.28 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q3LXA3.
Amino-acid sequence (575 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TKFC?
The strongest Open Targets associations for TKFC are triokinase and FMN cyclase deficiency syndrome, Congenital cataract - hypertrophic cardiomyopathy - mitochondrial myopathy, COVID-19, inborn errors of metabolism and skin pigmentation.
How long is the TKFC protein?
The Homo sapiens TKFC protein (UniProt Q3LXA3) is 575 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q3LXA3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q3LXA3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.