Probable tubulin polyglutamylase TTLL9 (TTLL9)
Homo sapiens — UniProt Q3SXZ7
Data last refreshed: (UniProt release unknown)
Key facts
Probable tubulin polyglutamylase TTLL9 (TTLL9) is a protein from Homo sapiens identified by UniProt accession Q3SXZ7, 439 residues long. MolForge cross-references it against 0 known binders and 105 disease associations.
- UniProt accession: Q3SXZ7; gene symbol TTLL9.
- Organism: Homo sapiens.
- Length: 439 amino acids.
- Top disease associations (Open Targets): Red cell distribution width, azoospermia and male infertility with teratozoospermia due to single gene mutation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Probable tubulin polyglutamylase TTLL9 |
|---|---|
| UniProt accession | Q3SXZ7 |
| Gene | TTLL9 |
| Organism | Homo sapiens |
| Length | 439 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (105)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.22
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- partial chromosome Y deletion · score 0.07
- spermatogenic failure 65 · score 0.07
- spermatogenic failure 56 · score 0.07
- spermatogenic failure, X-linked, 3 · score 0.07
- spermatogenic failure 40 · score 0.07
- spermatogenic failure 72 · score 0.07
- spermatogenic failure 10 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q3SXZ7-F1 | alphafold | PREDICTED | 78.65 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q3SXZ7.
Amino-acid sequence (439 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TTLL9?
The strongest Open Targets associations for TTLL9 are Red cell distribution width, azoospermia, male infertility with teratozoospermia due to single gene mutation, partial chromosome Y deletion and spermatogenic failure 65.
How long is the TTLL9 protein?
The Homo sapiens TTLL9 protein (UniProt Q3SXZ7) is 439 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q3SXZ7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q3SXZ7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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