Transcription factor Sp6 (SP6)
Homo sapiens — UniProt Q3SY56
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor Sp6 (SP6) is a protein from Homo sapiens identified by UniProt accession Q3SY56, 376 residues long. MolForge cross-references it against 0 known binders and 563 disease associations.
- UniProt accession: Q3SY56; gene symbol SP6.
- Organism: Homo sapiens.
- Length: 376 amino acids.
- Top disease associations (Open Targets): amelogenesis imperfecta, IIa 1K, amelogenesis imperfecta and Hypoplastic amelogenesis imperfecta.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor Sp6 |
|---|---|
| UniProt accession | Q3SY56 |
| Gene | SP6 |
| Organism | Homo sapiens |
| Length | 376 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (563)
Diseases linked to this target (Open Targets).
- amelogenesis imperfecta, IIa 1K · score 0.51
- amelogenesis imperfecta · score 0.46
- Hypoplastic amelogenesis imperfecta · score 0.39
- hair color · score 0.28
- prostate carcinoma · score 0.26
- hair colour measurement · score 0.23
- creatinine measurement · score 0.22
- skin pigmentation · score 0.21
- body fat distribution · score 0.14
- drug use measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q3SY56-F1 | alphafold | PREDICTED | 52.00 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q3SY56.
Amino-acid sequence (376 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SP6?
The strongest Open Targets associations for SP6 are amelogenesis imperfecta, IIa 1K, amelogenesis imperfecta, Hypoplastic amelogenesis imperfecta, hair color and prostate carcinoma.
How long is the SP6 protein?
The Homo sapiens SP6 protein (UniProt Q3SY56) is 376 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q3SY56 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q3SY56 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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