GON-4-like protein (GON4L)

Homo sapiens — UniProt Q3T8J9

Gene: GON4LHomo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

GON-4-like protein (GON4L) is a protein from Homo sapiens identified by UniProt accession Q3T8J9, 2241 residues long. MolForge cross-references it against 0 known binders and 163 disease associations.

UniProt accession: Q3T8J9; gene symbol GON4L.
Organism: Homo sapiens.
Length: 2241 amino acids.
Top disease associations (Open Targets): neurodegenerative disease, blood protein measurement and gastric carcinoma.
3D structure: AlphaFold model available.

Target properties

Protein name	GON-4-like protein
UniProt accession	Q3T8J9
Gene	GON4L
Organism	Homo sapiens
Length	2241 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (163)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.54
blood protein measurement · score 0.30
gastric carcinoma · score 0.25
urate measurement · score 0.19
blood urea nitrogen measurement · score 0.19
brain volume measurement · score 0.19
body mass index · score 0.12
serum gamma-glutamyl transferase measurement · score 0.12
cancer antigen 15.3 measurement · score 0.11
ependymoma · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q3T8J9-F1	alphafold	PREDICTED	47.69	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q3T8J9.

Amino-acid sequence (2241 residues)

MLPCKKRRTT VTESLQHKGN QEENNVDLES AVKPESDQVK DLSSVSLSWD PSHGRVAGFE VQSLQDAGNQ LGMEDTSLSS GMLTQNTNVP ILEGVDVAIS QGITLPSLES FHPLNIHIGK GKLHATGSKR GKKMTLRPGP VTQEDRCDHL TLKEPFSGEP SEEVKEEGGK PQMNSEGEIP SLPSGSQSAK PVSQPRKSTQ PDVCASPQEK PLRTLFHQPE EEIEDGGLFI PMEEQDNEES EKRRKKKKGT KRKRDGRGQE GTLAYDLKLD DMLDRTLEDG AKQHNLTAVN VRNILHEVIT NEHVVAMMKA AISETEDMPM FEPKMTRSKL KEVVEKGVVI PTWNISPIKK ANEIKPPQFV DIHLEEDDSS DEEYQPDDEE EDETAEESLL ESDVESTASS PRGAKKSRLR QSSEMTETDE ESGILSEAEK VTTPAIRHIS AEVVPMGPPP PPKPKQTRDS TFMEKLHAVD EELASSPVCM DSFQPMDDSL IAFRTRSKMP LKDVPLGQLE AELQAPDITP DMYDPNTADD EDWKMWLGGL MNDDVGNEDE ADDDDDPEYN FLEDLDEPDT EDFRTDRAVR ITKKEVNELM EELFETFQDE MGFSNMEDDG PEEEECVAEP RPNFNTPQAL RFEEPLANLL NEQHRTVKEL FEQLKMKKSS AKQLQEVEKV KPQSEKVHQT LILDPAQRKR LQQQMQQHVQ LLTQIHLLAT CNPNLNPEAT TTRIFLKELG TFAQSSIALH HQYNPKFQTL FQPCNLMGAM QLIEDFSTHV SIDCSPHKTV KKTANEFPCL PKQVAWILAT SKVFMYPELL PVCSLKAKNP QDKIVFTKAE DNLLALGLKH FEGTEFPNPL ISKYLLTCKT AHQLTVRIKN LNMNRAPDNI IKFYKKTKQL PVLGKCCEEI QPHQWKPPIE REEHRLPFWL KASLPSIQEE LRHMADGARE VGNMTGTTEI NSDRSLEKDN LELGSESRYP LLLPKGVVLK LKPVATRFPR KAWRQKRSSV LKPLLIQPSP SLQPSFNPGK TPARSTHSEA PPSKMVLRIP HPIQPATVLQ TVPGVPPLGV SGGESFESPA ALPAVPPEAR TSFPLSESQT LLSSAPVPKV MLPSLAPSKF RKPYVRRRPS KRRGVKASPC MKPAPVIHHP ASVIFTVPAT TVKIVSLGGG CNMIQPVNAA VAQSPQTIPI TTLLVNPTSF PCPLNQSLVA SSVSPLIVSG NSVNLPIPST PEDKAHVNVD IACAVADGEN AFQGLEPKLE PQELSPLSAT VFPKVEHSPG PPLADAECQE GLSENSACRW TVVKTEEGRQ ALEPLPQGIQ ESLNNPTPGD LEEIVKMEPE EAREEISGSP ERDICDDIKV EHAVELDTGA PSEELSSAGE VTKQTVLQKE EERSQPTKTP SSSQEPPDEG TSGTDVNKGS SKNALSSMDP EVRLSSPPGK PEDSSSVDGQ SVGTPVGPET GGEKNGPEEE EEEDFDDLTQ DEEDEMSSAS EESVLSVPEL QETMEKLTWL ASERRMSQEG ESEEENSQEE NSEPEEEEEE EAEGMESLQK EDEMTDEAVG DSAEKPPTFA SPETAPEVET SRTPPGESIK AAGKGRNNHR ARNKRGSRAR ASKDTSKLLL LYDEDILERD PLREQKDLAF AQAYLTRVRE ALQHIPGKYE DFLQVIYEFE SSTQRRTAVD LYKSLQILLQ DWPQLLKDFA AFLLPEQALA CGLFEEQQAF EKSRKFLRQL EICFAENPSH HQKIIKVLQG CADCLPQEIT ELKTQMWQLL KGHDHLQDEF SIFFDHLRPA ASRMGDFEEI NWTEEKEYEF DGFEEVALPD VEEEEEPPKI PTASKNKRKK EIGVQNHDKE TEWPDGAKDC ACSCHEGGPD SKLKKSKRRS CSHCSSKVCD SKSYKSKEPH ELVGSSPHRE ASPMPGAKEA GQGKDMMEEE APEERESTEA TQSRTVRTTR KGEMPVSAGL AVGSTLPSPR EVTVTERLLL DGPPPHSPET PQFPPTTGAV LYTVKRNQVG PEVRSCPKAS PRLQKEREGQ KAVSESEALM LVWDASETEK LPGTVEPPAS FLSPVSSKTR DAGRRHVSGK PDTQERWLPS SRARVKTRDR TCPVHESPSG IDTSETSPKA PRGGLAKDSG TQAKGPEGEQ QPKAAEATVC ANNSKVSSTG EKVVLWTREA DRVILTMCQE QGAQPQTFNI ISQQLGNKTP AEVSHRFREL MQLFHTACEA SSEDEDDATS TSNADQLSDH GDLLSEEELD E

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with GON4L?

The strongest Open Targets associations for GON4L are neurodegenerative disease, blood protein measurement, gastric carcinoma, urate measurement and blood urea nitrogen measurement.

How long is the GON4L protein?

The Homo sapiens GON4L protein (UniProt Q3T8J9) is 2241 amino acids long.

Browse: Targets: G · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q3T8J9 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q3T8J9 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.