N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB)
Homo sapiens — UniProt Q3T906
Data last refreshed: (UniProt release unknown)
Key facts
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB) is a protein from Homo sapiens identified by UniProt accession Q3T906, 1256 residues long. MolForge cross-references it against 0 known binders and 191 disease associations.
- UniProt accession: Q3T906; gene symbol GNPTAB.
- Organism: Homo sapiens.
- Length: 1256 amino acids.
- Top disease associations (Open Targets): mucolipidosis type III, alpha/beta, mucolipidosis type II and mucolipidosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | N-acetylglucosamine-1-phosphotransferase subunits alpha/beta |
|---|---|
| UniProt accession | Q3T906 |
| Gene | GNPTAB |
| Organism | Homo sapiens |
| Length | 1256 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (191)
Diseases linked to this target (Open Targets).
- mucolipidosis type III, alpha/beta · score 0.85
- mucolipidosis type II · score 0.83
- mucolipidosis · score 0.55
- Joubert syndrome and related disorders · score 0.51
- genetic disorder · score 0.51
- neurodegenerative disease · score 0.50
- mucopolysaccharidosis type 3A · score 0.50
- Abnormality of metabolism/homeostasis · score 0.41
- blood protein measurement · score 0.38
- lysosomal storage disease · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q3T906-F1 | alphafold | PREDICTED | 71.64 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q3T906.
Amino-acid sequence (1256 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GNPTAB?
The strongest Open Targets associations for GNPTAB are mucolipidosis type III, alpha/beta, mucolipidosis type II, mucolipidosis, Joubert syndrome and related disorders and genetic disorder.
How long is the GNPTAB protein?
The Homo sapiens GNPTAB protein (UniProt Q3T906) is 1256 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q3T906 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q3T906 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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