Transforming growth factor beta regulator 1 (TBRG1)
Homo sapiens — UniProt Q3YBR2
Data last refreshed: (UniProt release unknown)
Key facts
Transforming growth factor beta regulator 1 (TBRG1) is a protein from Homo sapiens identified by UniProt accession Q3YBR2, 411 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.
- UniProt accession: Q3YBR2; gene symbol TBRG1.
- Organism: Homo sapiens.
- Length: 411 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Intellectual disability and cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transforming growth factor beta regulator 1 |
|---|---|
| UniProt accession | Q3YBR2 |
| Gene | TBRG1 |
| Organism | Homo sapiens |
| Length | 411 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (37)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- Intellectual disability · score 0.26
- cancer · score 0.06
- schizophrenia · score 0.04
- neoplasm · score 0.04
- Li-Fraumeni syndrome · score 0.04
- erythroleukemia, familial, susceptibility to · score 0.04
- familial atypical multiple mole melanoma syndrome · score 0.04
- NUT midline carcinoma · score 0.04
- immunodeficiency 84 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q3YBR2-F1 | alphafold | PREDICTED | 71.80 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q3YBR2.
Amino-acid sequence (411 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TBRG1?
The strongest Open Targets associations for TBRG1 are neurodegenerative disease, Intellectual disability, cancer, schizophrenia and neoplasm.
How long is the TBRG1 protein?
The Homo sapiens TBRG1 protein (UniProt Q3YBR2) is 411 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q3YBR2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q3YBR2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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