Vacuolar ATPase assembly integral membrane protein VMA21 (VMA21)
Homo sapiens — UniProt Q3ZAQ7
Data last refreshed: (UniProt release unknown)
Key facts
Vacuolar ATPase assembly integral membrane protein VMA21 (VMA21) is a protein from Homo sapiens identified by UniProt accession Q3ZAQ7, 101 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.
- UniProt accession: Q3ZAQ7; gene symbol VMA21.
- Organism: Homo sapiens.
- Length: 101 amino acids.
- Top disease associations (Open Targets): X-linked myopathy with excessive autophagy, neurodegenerative disease and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Vacuolar ATPase assembly integral membrane protein VMA21 |
|---|---|
| UniProt accession | Q3ZAQ7 |
| Gene | VMA21 |
| Organism | Homo sapiens |
| Length | 101 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (15)
Diseases linked to this target (Open Targets).
- X-linked myopathy with excessive autophagy · score 0.73
- neurodegenerative disease · score 0.47
- genetic disorder · score 0.39
- Ataxia-telangiectasia · score 0.01
- lumbar disc degeneration · score 0.01
- Alzheimer disease · score 0.00
- neoplasm · score 0.00
- acute quadriplegic myopathy · score 0.00
- Sepsis · score 0.00
- lysosomal storage disease · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q3ZAQ7-F1 | alphafold | PREDICTED | 70.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q3ZAQ7.
Amino-acid sequence (101 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with VMA21?
The strongest Open Targets associations for VMA21 are X-linked myopathy with excessive autophagy, neurodegenerative disease, genetic disorder, Ataxia-telangiectasia and lumbar disc degeneration.
How long is the VMA21 protein?
The Homo sapiens VMA21 protein (UniProt Q3ZAQ7) is 101 amino acids long.
Browse: Targets: V · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q3ZAQ7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q3ZAQ7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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