Otogelin-like protein (OTOGL)

Homo sapiens — UniProt Q3ZCN5

Gene: OTOGLHomo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Otogelin-like protein (OTOGL) is a protein from Homo sapiens identified by UniProt accession Q3ZCN5, 2353 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

UniProt accession: Q3ZCN5; gene symbol OTOGL.
Organism: Homo sapiens.
Length: 2353 amino acids.
Top disease associations (Open Targets): hearing loss, autosomal recessive, Rare genetic deafness and nonsyndromic genetic hearing loss.
3D structure: AlphaFold model available.

Target properties

Protein name	Otogelin-like protein
UniProt accession	Q3ZCN5
Gene	OTOGL
Organism	Homo sapiens
Length	2353 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

hearing loss, autosomal recessive · score 0.65
Rare genetic deafness · score 0.53
nonsyndromic genetic hearing loss · score 0.44
genetic disorder · score 0.34
deafness · score 0.30
hemangioma · score 0.28
autosomal dominant nonsyndromic hearing loss · score 0.27
lymphangioma · score 0.25
Vertigo · score 0.21
Hearing impairment · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q3ZCN5-F1	alphafold	PREDICTED	72.00	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q3ZCN5.

Amino-acid sequence (2353 residues)

MNIVRKLNLM IPWSIFLLHV LLFSLQEYIC ASSILMGTSK NGFNENRQKR ALLAAQFEAT SPRYFFHDAI NWGESKIKGS CPYECLNGAF CSKTGTCDCQ IFQALGTRCQ IIPNMGNGRD GICKTWGQYH FETFDGIYYY FPGNCSYIFA KDCGDLEPRY TVWVHNSPKC LGSVYSCYRS ISLFFSNQEE IRIYGHEIKK NGISLTLPQT IGQIFIEKLA DYILVKTTFG FSLAWDGISG IYLKLSEDHK GKSCGLCGNY NDIQSDDFII LQEDYTEDIA MFANSWSVQT PDDTKCVLTP SDFPNPCSSG MPAFEAIFFK CQILLQFPFL SCHEYIDPYL YIASCVNDLC KTDDDETYCR AATEYARACS HAGYPIQDWR DDFPACTDKC DDSFVHRDCI SCCPPTCTFE KQCLGSNLHC LDGCYCPDGL VMDNGTCISL ENCPCGFHGL AYSVGSKIEQ ECTECVCVGG VWNCTEQDCP VQCSVVGDSH FTTFDGRHYS FIGMCQYILV KGTGKDKFTI TLQKAPCEQN LGLVCLQSIT LILEDDFNKQ VTLGRGGQIL TSPNQGFNLN GIVEIQTLSS LFILLKTTFG LKILFAIDGE RIYIQLTSAW KRRTLGLCGT FNGNIRDDFL SPSGMIEGTP QLHANAWRVS STCFAPVHVP VVDPCNINQQ NIGYAAHCDV IHQELFAPCH IYISPGLYYQ LCRHDACKCG SSCLCNALAH YAYLCGQHGV PIDFRTQISF CAVVCQKGML YHHCSSFCLH SCISLSSPEQ CSDDCAEGCN CPEGKFYEDT LNFCVPIFHC RCHYRGSVYQ PGELIPTPSG LCQCSNGTVK CDELATPSAV HICPEGKEYF DCRFPDPELP AGGVNCETTC ANLAMNFTCT PSSPCISGCV CAPGMAEHRG KCYVPESCPC IWKDWEYLSG EVIATPCYTC VCRRGMFNCT YYPCPAVCTI YGDRHYYSFD GLEYDYISDC QVFLIKSADD SDISVIAQNK KCFDNDIVCS KSVLISVGDT EIYLNDTPYK QKQSGFFLEN KSTYQLWKAG YYIVVYFPEK DITILWDRKT TIHIKVGPQW KNKLSGLCGN FDKCTSNDMT TSNNLEVRNA RVFGDSWALG QCESPDETIK PCEAHQNKFP YAKKECSILY SDIFASCRNV IDVTSFAKNC HEDTCNCNLG GDCECLCTSI AAYAYKCCQE GISIHWRSST VCSLDCEYYN EGLGEGPYML ASYGQSGLVL GANMTSRSVF CLPRSSVHTS LFFYFMITPG LFKEKVSSLA LVSLESAERP NYFLYVHDND TLSLELWEAN SAFHRRATFF HHQGLWIPGY SAFELYSKKG FFIIFTDSSV KASKYDDSEE FKHSSSFSIE EIQAAVPYRK MCEWRYEPCA TPCFKTCSDP EALACKFLPP VEGCLPYCPK NMILDEVTLK CVYPRDCIPV IPTEPTLMPP AKPTVPMFTV WEMITPSDIT VFDMLTPTTG LECEPQKFDP VYDCSQYICL NMEWQLYNWS LNCPKDVEMP DCGFRGRPVQ VNSDICCPEW ECPCRCSMLS ELSIITFDGN NAALYSMASY ILVRIPGEII VAHIEKCSMN QNGNSLKKLA PSGRISGLCF KKLNVTTPIH KIIVNRLARK VEVDSIVVPL PFSSQELSIE DSGSMYVITT PAGLIIKWSH LTGIIDIHFG FRFNLSSYTE GLCGICNEDP DDDLRMQNGT IITNMEDIGL FIESWEIEKS FEVTMRRPVR NCTEHDCSQC IDLLNRRIFI PCHDKVSPED FCEKMWINYT YFWNYECDAL SAYVALCNKF DICIQWRTPD YCSLSCPEGK EYQPCVRPCE ARTCLNQWFY GHTSCLNLRE DCVCKVGTIL HRPHSAQCIP EKECACTDSE DQPRTAGEIW NGGIDECTLY KCLENGSIIP IEPDCDEEPT PVCEREAEVV MGIIDKWTCC SKEVCGCDTT LCETSIPTCT NSQKLIVGHS PLSCCPQYKC ECDPLKCPSI STPECREDQF MIQVRQEEPC CFSPFCVCES CTKPVPLCHD GEFLTVDLNS THFCCPQYYC VCEPNLCPMP LLNCAEDMNL VKENVSGQCC PTWHCECNCE NLIMPTCEVG EFTAIDHNFQ SDCGCIQYLC EKDDVCVFQE VSVLNPGQSM IKYLEEDFCY AIECLEEKDN HTGFHTLNFT LVNCSKKCDV HQVYTPSPSD YGCCGTCKNV SCKFHMENGT SVVYAVGSTW HYNCTTYECV KTDEGAIILN YTMVCPPFNE TECKMNEGIV KLYNEGCCKI CKREERICQK VIIKSVIRKQ DCMSQSPINV ASCDGKCPSA TIYNINIESH LRFCKCCREN GVRNLSVPLY CSGNGTEIMY TLQEPIDCTC QWN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with OTOGL?

The strongest Open Targets associations for OTOGL are hearing loss, autosomal recessive, Rare genetic deafness, nonsyndromic genetic hearing loss, genetic disorder and deafness.

How long is the OTOGL protein?

The Homo sapiens OTOGL protein (UniProt Q3ZCN5) is 2353 amino acids long.

Browse: Targets: O · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q3ZCN5 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q3ZCN5 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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