Spermatogenesis-associated serine-rich protein 1 (SPATS1)
Homo sapiens — UniProt Q496A3
Data last refreshed: (UniProt release unknown)
Key facts
Spermatogenesis-associated serine-rich protein 1 (SPATS1) is a protein from Homo sapiens identified by UniProt accession Q496A3, 300 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.
- UniProt accession: Q496A3; gene symbol SPATS1.
- Organism: Homo sapiens.
- Length: 300 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, monocyte count and lymphocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Spermatogenesis-associated serine-rich protein 1 |
|---|---|
| UniProt accession | Q496A3 |
| Gene | SPATS1 |
| Organism | Homo sapiens |
| Length | 300 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (37)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.19
- monocyte count · score 0.08
- lymphocyte count · score 0.08
- monocyte percentage of leukocytes · score 0.08
- alkaline phosphatase measurement · score 0.08
- heel bone mineral density · score 0.07
- lymphocyte:monocyte ratio · score 0.06
- stroke · score 0.06
- ossification of the posterior longitudinal ligament of the spine · score 0.06
- blood phosphate measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q496A3-F1 | alphafold | PREDICTED | 57.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q496A3.
Amino-acid sequence (300 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPATS1?
The strongest Open Targets associations for SPATS1 are neurodegenerative disease, monocyte count, lymphocyte count, monocyte percentage of leukocytes and alkaline phosphatase measurement.
How long is the SPATS1 protein?
The Homo sapiens SPATS1 protein (UniProt Q496A3) is 300 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q496A3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q496A3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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