Protein FAM135B (FAM135B)
Homo sapiens — UniProt Q49AJ0
Data last refreshed: (UniProt release unknown)
Key facts
Protein FAM135B (FAM135B) is a protein from Homo sapiens identified by UniProt accession Q49AJ0, 1406 residues long. MolForge cross-references it against 0 known binders and 163 disease associations.
- UniProt accession: Q49AJ0; gene symbol FAM135B.
- Organism: Homo sapiens.
- Length: 1406 amino acids.
- Top disease associations (Open Targets): family history of Alzheimer’s disease, antisocial behaviour measurement and attention deficit hyperactivity disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein FAM135B |
|---|---|
| UniProt accession | Q49AJ0 |
| Gene | FAM135B |
| Organism | Homo sapiens |
| Length | 1406 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (163)
Diseases linked to this target (Open Targets).
- family history of Alzheimer’s disease · score 0.31
- antisocial behaviour measurement · score 0.30
- attention deficit hyperactivity disorder · score 0.30
- substance abuse · score 0.30
- squamous cell lung carcinoma · score 0.28
- head and neck squamous cell carcinoma · score 0.23
- Uterine Carcinosarcoma · score 0.22
- esophageal squamous cell carcinoma · score 0.20
- breast carcinoma · score 0.19
- visual perception measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q49AJ0-F1 | alphafold | PREDICTED | 60.95 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q49AJ0.
Amino-acid sequence (1406 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FAM135B?
The strongest Open Targets associations for FAM135B are family history of Alzheimer’s disease, antisocial behaviour measurement, attention deficit hyperactivity disorder, substance abuse and squamous cell lung carcinoma.
How long is the FAM135B protein?
The Homo sapiens FAM135B protein (UniProt Q49AJ0) is 1406 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q49AJ0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q49AJ0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.