About Protein FAM135B
Protein FAM135B (FAM135B) is a protein
from Homo sapiens identified by UniProt accession
Q49AJ0, 1406 residues long.
MolForge cross-references it against 0 known binders and
163 disease associations.
Target properties
| Protein name | Protein FAM135B |
|---|
| UniProt accession | Q49AJ0 |
|---|
| Gene | FAM135B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 1406 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (163)
Diseases linked to this target (Open Targets).
- family history of Alzheimer’s disease · score 0.31
- antisocial behaviour measurement · score 0.30
- attention deficit hyperactivity disorder · score 0.30
- substance abuse · score 0.30
- squamous cell lung carcinoma · score 0.28
- head and neck squamous cell carcinoma · score 0.23
- Uterine Carcinosarcoma · score 0.22
- esophageal squamous cell carcinoma · score 0.20
- breast carcinoma · score 0.19
- visual perception measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q49AJ0-F1 | alphafold | PREDICTED | 60.95 | — |
Amino-acid sequence (1406 residues)
MSEIQGTVEF SVELHKFYNV DLFQRGYYQI RVTLKVSSRI PHRLSASIAG QTESSSLHSA CVHDSTVHSR VFQILYRNEE VPINDAVVFR VHLLLGGERM EDALSEVDFQ LKVDLHFTDS EQQLRDVAGA PMVSSRTLGL HFHPRNGLHH QVPVMFDYFH LSVISVTVHA ALVALQQPLI SFTRPGRGSW LGKGGPDTGQ EQSIISLENL VFGAGYCKPT SSEGSFYITS ENCMQHAHKW HRDLCLLLLH AYRGLRLHFL VIMRDIPELP HTELEALAVE ETLSQLCSEL QMLNNPEKIA EQISKDLAWL TSHMMTLWTQ FLDTVTLHSQ VTTYLTQEHH TLRVRRFSEA FFYMEHQKLA VLTFQENLIQ THSQLSLDIR NSEYLTSMPP LPAECLDIDG DWNTLPVIFE DRYVDCPATG HNLSVYPNFD VPVTSPTIMN LKDKEDNCMV NSNLSFREDL VLSTIKPSQM DSDEEVIRCP EPGENVATQN HMDMCSESQV YISIGEFQNK AGVPEDECWT GQTSDAGTYP VADVDTSRRS PGPEDGQAPV LTYIDVKSSN KNPSRAEPLV AFNAQHESRS SRDKYGLDRT GLSKVVVGGS HQNAISSDKT TLHELSTLGK GIDQEGKMVL LSLKLTPSEP CDPLSSTLRE PLDIRSSLKD SHTEEQEELS VLSGVIKRSS SIISDSGIES EPSSVAWSEA RSRALELPSD REVLHPFVRR HALHRNSLEG GHTESNTSLP SGIQASLTSI SSLPFEEDER EVALTKLTKS VSAPHISSPE EAAEDADTKQ QDGGFAEPSD MHSKSQGSPG SCSQLCGDSG TDAGADHPLV EIVLDADNQQ GPGYIDIPKG KGKQFDAQGH CLPDGRTENT PGVETKGLNL KIPRVIALEN PRTRSLHRAL EETPKGMPKD LNVGQQALSN SGISEVEGLS QHQVPELSCT SAADAINRNS TGQQSQSGSP CIMDDTAFNR GVNAFPEAKH KAGTVCPTVT HSVHSQVLKN QELKAGTSIM GSHLTSAETF TLDSLKAVEV VNLSVSCTAT CLPFSSVPKE TPARAGFSSK QTLFPITHQP LGSFGVVSTH SSTLDEEVSE RMFSFYQAKE KFKKELKIEG FLYSDLTVLA SDIPYFPPEE EEENLEDGIH LVVCVHGLDG NSADLRLVKT FIELGLPGGK LDFLMSEKNQ MDTFADFDTM TDRLLDEIIQ HIQLYNLSIS RISFIGHSLG NIIIRSVLTR PRFRYYLNKL HTFLSLSGPH LGTLYNNSTL VSTGLWLMQK LKKSGSLLQL TFRDNADLRK CFLYQLSQKT GLQYFKNVVL VASPQDRYVP FHSARIEMCK TALKDRHTGP VYAEMINNLL GPLVEAKDCT LIRHNVFHAL PNTANTLIGR AAHIAVLDSE LFLEKFFLVA GLNYFK
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