Erythroferrone (ERFE)

About Erythroferrone

Erythroferrone (ERFE) is a protein from Homo sapiens identified by UniProt accession Q4G0M1, 354 residues long. MolForge cross-references it against 0 known binders and 164 disease associations.

Target properties

Protein name	Erythroferrone
UniProt accession	Q4G0M1
Gene	ERFE
Organism	Homo sapiens
Length	354 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (164)

Diseases linked to this target (Open Targets).

mean corpuscular hemoglobin concentration · score 0.44
mean corpuscular hemoglobin · score 0.42
mean corpuscular volume · score 0.40
hemoglobin measurement · score 0.38
Red cell distribution width · score 0.37
hematocrit · score 0.33
transferrin saturation measurement · score 0.23
serum iron measurement · score 0.23
phospholipid measurement · score 0.12
hemoglobin A1 measurement · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q4G0M1-F1	alphafold	PREDICTED	69.97	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q4G0M1.

Amino-acid sequence (354 residues)

MAPARRPAGA RLLLVYAGLL AAAAAGLGSP EPGAPSRSRA RREPPPGNEL PRGPGESRAG PAARPPEPTA ERAHSVDPRD AWMLFVRQSD KGVNGKKRSR GKAKKLKFGL PGPPGPPGPQ GPPGPIIPPE ALLKEFQLLL KGAVRQRERA EPEPCTCGPA GPVAASLAPV SATAGEDDDD VVGDVLALLA APLAPGPRAP RVEAAFLCRL RRDALVERRA LHELGVYYLP DAEGAFRRGP GLNLTSGQYR APVAGFYALA ATLHVALGEP PRRGPPRPRD HLRLLICIQS RCQRNASLEA IMGLESSSEL FTISVNGVLY LQMGQWTSVF LDNASGCSLT VRSGSHFSAV LLGV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards