NAD kinase 2, mitochondrial (NADK2)

About NAD kinase 2, mitochondrial

NAD kinase 2, mitochondrial (NADK2) is a protein from Homo sapiens identified by UniProt accession Q4G0N4, 442 residues long. MolForge cross-references it against 0 known binders and 125 disease associations.

Target properties

Protein name	NAD kinase 2, mitochondrial
UniProt accession	Q4G0N4
Gene	NADK2
Organism	Homo sapiens
Length	442 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (125)

Diseases linked to this target (Open Targets).

progressive encephalopathy with leukodystrophy due to DECR deficiency · score 0.70
sex hormone-binding globulin measurement · score 0.42
neurodegenerative disease · score 0.36
type 2 diabetes mellitus · score 0.22
genetic disorder · score 0.19
lean body mass · score 0.16
hypertension · score 0.12
fat body mass · score 0.10
intraocular pressure measurement · score 0.09
renal tubule disease · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q4G0N4-F1	alphafold	PREDICTED	83.09	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q4G0N4.

Amino-acid sequence (442 residues)

MTCYRGFLLG SCCRVAGGRA AALRGPGAGG PAARPRLGGD GGGRRHLGQG QPRELAGCGS RADGGFRPSR VVVVAKTTRY EFEQQRYRYA ELSEEDLKQL LALKGSSYSG LLERHHIHTK NVEHIIDSLR NEGIEVRLVK RREYDEETVR WADAVIAAGG DGTMLLAASK VLDRLKPVIG VNTDPERSEG HLCLPVRYTH SFPEALQKFY RGEFRWLWRQ RIRLYLEGTG INPVPVDLHE QQLSLNQHNR ALNIERAHDE RSEASGPQLL PVRALNEVFI GESLSSRASY YEISVDDGPW EKQKSSGLNL CTGTGSKAWS FNINRVATQA VEDVLNIAKR QGNLSLPLNR ELVEKVTNEY NESLLYSPEE PKILFSIREP IANRVFSSSR QRCFSSKVCV RSRCWDACMV VDGGTSFEFN DGAIASMMIN KEDELRTVLL EQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards