Cilia- and flagella-associated protein 221 (CFAP221)
Homo sapiens — UniProt Q4G0U5
Data last refreshed: (UniProt release unknown)
Key facts
Cilia- and flagella-associated protein 221 (CFAP221) is a protein from Homo sapiens identified by UniProt accession Q4G0U5, 840 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.
- UniProt accession: Q4G0U5; gene symbol CFAP221.
- Organism: Homo sapiens.
- Length: 840 amino acids.
- Top disease associations (Open Targets): primary ciliary dyskinesia, lymphocyte count and mathematical ability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cilia- and flagella-associated protein 221 |
|---|---|
| UniProt accession | Q4G0U5 |
| Gene | CFAP221 |
| Organism | Homo sapiens |
| Length | 840 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (15)
Diseases linked to this target (Open Targets).
- primary ciliary dyskinesia · score 0.47
- lymphocyte count · score 0.07
- mathematical ability · score 0.04
- Abnormal sperm morphology · score 0.01
- Hydrocephalus · score 0.01
- squamous cell carcinoma · score 0.01
- Crohn's disease · score 0.01
- pneumococcal infection · score 0.01
- male infertility · score 0.00
- non-alcoholic steatohepatitis · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q4G0U5-F1 | alphafold | PREDICTED | 63.35 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q4G0U5.
Amino-acid sequence (840 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CFAP221?
The strongest Open Targets associations for CFAP221 are primary ciliary dyskinesia, lymphocyte count, mathematical ability, Abnormal sperm morphology and Hydrocephalus.
How long is the CFAP221 protein?
The Homo sapiens CFAP221 protein (UniProt Q4G0U5) is 840 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q4G0U5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q4G0U5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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