BTB/POZ domain-containing protein KCTD21 (KCTD21)
Homo sapiens — UniProt Q4G0X4
Data last refreshed: (UniProt release unknown)
Key facts
BTB/POZ domain-containing protein KCTD21 (KCTD21) is a protein from Homo sapiens identified by UniProt accession Q4G0X4, 260 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.
- UniProt accession: Q4G0X4; gene symbol KCTD21.
- Organism: Homo sapiens.
- Length: 260 amino acids.
- Top disease associations (Open Targets): diastolic blood pressure, protein measurement and non-small cell lung carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | BTB/POZ domain-containing protein KCTD21 |
|---|---|
| UniProt accession | Q4G0X4 |
| Gene | KCTD21 |
| Organism | Homo sapiens |
| Length | 260 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (57)
Diseases linked to this target (Open Targets).
- diastolic blood pressure · score 0.12
- protein measurement · score 0.07
- non-small cell lung carcinoma · score 0.07
- body mass index · score 0.07
- glomerular filtration rate · score 0.07
- age at menopause · score 0.07
- age at menarche · score 0.07
- L lactate dehydrogenase measurement · score 0.07
- serum alanine aminotransferase measurement · score 0.07
- creatinine measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q4G0X4-F1 | alphafold | PREDICTED | 89.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q4G0X4.
Amino-acid sequence (260 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KCTD21?
The strongest Open Targets associations for KCTD21 are diastolic blood pressure, protein measurement, non-small cell lung carcinoma, body mass index and glomerular filtration rate.
How long is the KCTD21 protein?
The Homo sapiens KCTD21 protein (UniProt Q4G0X4) is 260 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q4G0X4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q4G0X4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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