Coiled-coil domain-containing protein 40 (CCDC40)
Homo sapiens — UniProt Q4G0X9
Data last refreshed: (UniProt release unknown)
Key facts
Coiled-coil domain-containing protein 40 (CCDC40) is a protein from Homo sapiens identified by UniProt accession Q4G0X9, 1142 residues long. MolForge cross-references it against 0 known binders and 112 disease associations.
- UniProt accession: Q4G0X9; gene symbol CCDC40.
- Organism: Homo sapiens.
- Length: 1142 amino acids.
- Top disease associations (Open Targets): primary ciliary dyskinesia, Kartagener Syndrome and Bronchiectasis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Coiled-coil domain-containing protein 40 |
|---|---|
| UniProt accession | Q4G0X9 |
| Gene | CCDC40 |
| Organism | Homo sapiens |
| Length | 1142 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (112)
Diseases linked to this target (Open Targets).
- primary ciliary dyskinesia · score 0.76
- Kartagener Syndrome · score 0.40
- Bronchiectasis · score 0.37
- bronchiectasis · score 0.37
- combined immunodeficiency due to DOCK8 deficiency · score 0.34
- Heterotaxy · score 0.33
- Usher syndrome · score 0.27
- mean reticulocyte volume · score 0.17
- male infertility · score 0.14
- Glycogen storage disease due to acid maltase deficiency · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q4G0X9-F1 | alphafold | PREDICTED | 70.73 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q4G0X9.
Amino-acid sequence (1142 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CCDC40?
The strongest Open Targets associations for CCDC40 are primary ciliary dyskinesia, Kartagener Syndrome, Bronchiectasis, bronchiectasis and combined immunodeficiency due to DOCK8 deficiency.
How long is the CCDC40 protein?
The Homo sapiens CCDC40 protein (UniProt Q4G0X9) is 1142 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q4G0X9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q4G0X9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.