Minichromosome maintenance domain-containing protein 2 (MCMDC2)
Homo sapiens — UniProt Q4G0Z9
Data last refreshed: (UniProt release unknown)
Key facts
Minichromosome maintenance domain-containing protein 2 (MCMDC2) is a protein from Homo sapiens identified by UniProt accession Q4G0Z9, 681 residues long. MolForge cross-references it against 0 known binders and 116 disease associations.
- UniProt accession: Q4G0Z9; gene symbol MCMDC2.
- Organism: Homo sapiens.
- Length: 681 amino acids.
- Top disease associations (Open Targets): azoospermia, male infertility with azoospermia or oligozoospermia due to single gene mutation and gut microbiome measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Minichromosome maintenance domain-containing protein 2 |
|---|---|
| UniProt accession | Q4G0Z9 |
| Gene | MCMDC2 |
| Organism | Homo sapiens |
| Length | 681 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (116)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.35
- male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.35
- gut microbiome measurement · score 0.14
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- partial chromosome Y deletion · score 0.07
- primary ovarian insufficiency · score 0.06
- congenital bilateral absence of vas deferens · score 0.06
- spermatogenic failures 50 · score 0.06
- spermatogenic failure 59 · score 0.06
- spermatogenic failure 73 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q4G0Z9-F1 | alphafold | PREDICTED | 85.75 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q4G0Z9.
Amino-acid sequence (681 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MCMDC2?
The strongest Open Targets associations for MCMDC2 are azoospermia, male infertility with azoospermia or oligozoospermia due to single gene mutation, gut microbiome measurement, male infertility with teratozoospermia due to single gene mutation and partial chromosome Y deletion.
How long is the MCMDC2 protein?
The Homo sapiens MCMDC2 protein (UniProt Q4G0Z9) is 681 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q4G0Z9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q4G0Z9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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