Prolyl endopeptidase-like (PREPL)
Homo sapiens — UniProt Q4J6C6
Data last refreshed: (UniProt release unknown)
Key facts
Prolyl endopeptidase-like (PREPL) is a protein from Homo sapiens identified by UniProt accession Q4J6C6, 727 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.
- UniProt accession: Q4J6C6; gene symbol PREPL.
- Organism: Homo sapiens.
- Length: 727 amino acids.
- Top disease associations (Open Targets): Congenital myasthenic syndromes, cystinuria and hypotonia-cystinuria syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Prolyl endopeptidase-like |
|---|---|
| UniProt accession | Q4J6C6 |
| Gene | PREPL |
| Organism | Homo sapiens |
| Length | 727 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (57)
Diseases linked to this target (Open Targets).
- Congenital myasthenic syndromes · score 0.66
- cystinuria · score 0.56
- hypotonia-cystinuria syndrome · score 0.55
- cystine urolithiasis · score 0.42
- Premature ovarian insufficiency · score 0.42
- Hypotonia - cystinuria syndrome · score 0.37
- Atypical hypotonia - cystinuria syndrome · score 0.37
- protein measurement · score 0.34
- bone density · score 0.34
- urate measurement · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q4J6C6-F1 | alphafold | PREDICTED | 82.76 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q4J6C6.
Amino-acid sequence (727 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PREPL?
The strongest Open Targets associations for PREPL are Congenital myasthenic syndromes, cystinuria, hypotonia-cystinuria syndrome, cystine urolithiasis and Premature ovarian insufficiency.
How long is the PREPL protein?
The Homo sapiens PREPL protein (UniProt Q4J6C6) is 727 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q4J6C6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q4J6C6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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