Cell adhesion molecule-related/down-regulated by oncogenes (CDON)
Homo sapiens — UniProt Q4KMG0
Data last refreshed: (UniProt release unknown)
Key facts
Cell adhesion molecule-related/down-regulated by oncogenes (CDON) is a protein from Homo sapiens identified by UniProt accession Q4KMG0, 1287 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.
- UniProt accession: Q4KMG0; gene symbol CDON.
- Organism: Homo sapiens.
- Length: 1287 amino acids.
- Top disease associations (Open Targets): holoprosencephaly, pituitary stalk interruption syndrome and blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cell adhesion molecule-related/down-regulated by oncogenes |
|---|---|
| UniProt accession | Q4KMG0 |
| Gene | CDON |
| Organism | Homo sapiens |
| Length | 1287 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (120)
Diseases linked to this target (Open Targets).
- holoprosencephaly · score 0.74
- pituitary stalk interruption syndrome · score 0.46
- blood protein measurement · score 0.38
- alobar holoprosencephaly · score 0.37
- midline interhemispheric variant of holoprosencephaly · score 0.37
- septopreoptic holoprosencephaly · score 0.37
- microform holoprosencephaly · score 0.37
- semilobar holoprosencephaly · score 0.37
- lobar holoprosencephaly · score 0.37
- forced expiratory volume · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q4KMG0-F1 | alphafold | PREDICTED | 62.04 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q4KMG0.
Amino-acid sequence (1287 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CDON?
The strongest Open Targets associations for CDON are holoprosencephaly, pituitary stalk interruption syndrome, blood protein measurement, alobar holoprosencephaly and midline interhemispheric variant of holoprosencephaly.
How long is the CDON protein?
The Homo sapiens CDON protein (UniProt Q4KMG0) is 1287 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q4KMG0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q4KMG0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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