Transmembrane protein 52B (TMEM52B)
Homo sapiens — UniProt Q4KMG9
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 52B (TMEM52B) is a protein from Homo sapiens identified by UniProt accession Q4KMG9, 183 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: Q4KMG9; gene symbol TMEM52B.
- Organism: Homo sapiens.
- Length: 183 amino acids.
- Top disease associations (Open Targets): self reported educational attainment, lectin-like oxidized LDL receptor 1 measurement and cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 52B |
|---|---|
| UniProt accession | Q4KMG9 |
| Gene | TMEM52B |
| Organism | Homo sapiens |
| Length | 183 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.27
- lectin-like oxidized LDL receptor 1 measurement · score 0.19
- cancer · score 0.08
- gonorrhea · score 0.08
- nonpapillary renal cell carcinoma · score 0.07
- esophageal squamous cell carcinoma · score 0.07
- clear cell renal carcinoma · score 0.07
- neoplasm · score 0.06
- metastatic melanoma · score 0.05
- papillary renal cell carcinoma · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q4KMG9-F1 | alphafold | PREDICTED | 60.28 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q4KMG9.
Amino-acid sequence (183 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM52B?
The strongest Open Targets associations for TMEM52B are self reported educational attainment, lectin-like oxidized LDL receptor 1 measurement, cancer, gonorrhea and nonpapillary renal cell carcinoma.
How long is the TMEM52B protein?
The Homo sapiens TMEM52B protein (UniProt Q4KMG9) is 183 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q4KMG9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q4KMG9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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