Taperin (TPRN)
Homo sapiens — UniProt Q4KMQ1
Data last refreshed: (UniProt release unknown)
Key facts
Taperin (TPRN) is a protein from Homo sapiens identified by UniProt accession Q4KMQ1, 711 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.
- UniProt accession: Q4KMQ1; gene symbol TPRN.
- Organism: Homo sapiens.
- Length: 711 amino acids.
- Top disease associations (Open Targets): deafness, hearing loss, autosomal recessive and Rare genetic deafness.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Taperin |
|---|---|
| UniProt accession | Q4KMQ1 |
| Gene | TPRN |
| Organism | Homo sapiens |
| Length | 711 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (22)
Diseases linked to this target (Open Targets).
- deafness · score 0.64
- hearing loss, autosomal recessive · score 0.63
- Rare genetic deafness · score 0.46
- nonsyndromic genetic hearing loss · score 0.37
- hearing loss · score 0.37
- ear malformation · score 0.27
- Abnormality of the ear · score 0.27
- genetic disorder · score 0.19
- Hearing impairment · score 0.12
- balding measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q4KMQ1-F1 | alphafold | PREDICTED | 54.45 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q4KMQ1.
Amino-acid sequence (711 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TPRN?
The strongest Open Targets associations for TPRN are deafness, hearing loss, autosomal recessive, Rare genetic deafness, nonsyndromic genetic hearing loss and hearing loss.
How long is the TPRN protein?
The Homo sapiens TPRN protein (UniProt Q4KMQ1) is 711 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q4KMQ1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q4KMQ1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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