Beta-defensin 134 (DEFB134)
Homo sapiens — UniProt Q4QY38
Data last refreshed: (UniProt release unknown)
Key facts
Beta-defensin 134 (DEFB134) is a protein from Homo sapiens identified by UniProt accession Q4QY38, 66 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.
- UniProt accession: Q4QY38; gene symbol DEFB134.
- Organism: Homo sapiens.
- Length: 66 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, cutaneous melanoma and mathematical ability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Beta-defensin 134 |
|---|---|
| UniProt accession | Q4QY38 |
| Gene | DEFB134 |
| Organism | Homo sapiens |
| Length | 66 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (26)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.24
- cutaneous melanoma · score 0.23
- mathematical ability · score 0.22
- neuroticism measurement · score 0.21
- lymphocyte count · score 0.19
- gastric adenocarcinoma · score 0.14
- wellbeing measurement · score 0.11
- electrocardiography · score 0.07
- serum non-albumin protein measurement · score 0.07
- monocyte count · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q4QY38-F1 | alphafold | PREDICTED | 79.71 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q4QY38.
Amino-acid sequence (66 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DEFB134?
The strongest Open Targets associations for DEFB134 are neurodegenerative disease, cutaneous melanoma, mathematical ability, neuroticism measurement and lymphocyte count.
How long is the DEFB134 protein?
The Homo sapiens DEFB134 protein (UniProt Q4QY38) is 66 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q4QY38 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q4QY38 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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