Transmembrane protein 119 (TMEM119)
Homo sapiens — UniProt Q4V9L6
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 119 (TMEM119) is a protein from Homo sapiens identified by UniProt accession Q4V9L6, 283 residues long. MolForge cross-references it against 0 known binders and 145 disease associations.
- UniProt accession: Q4V9L6; gene symbol TMEM119.
- Organism: Homo sapiens.
- Length: 283 amino acids.
- Top disease associations (Open Targets): heel bone mineral density, intraocular pressure measurement and refractive error measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 119 |
|---|---|
| UniProt accession | Q4V9L6 |
| Gene | TMEM119 |
| Organism | Homo sapiens |
| Length | 283 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (145)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.41
- intraocular pressure measurement · score 0.38
- refractive error measurement · score 0.37
- blood phosphate measurement · score 0.34
- P-selectin glycoprotein ligand 1 measurement · score 0.28
- Abnormality of refraction · score 0.25
- optic disc size measurement · score 0.24
- blood protein measurement · score 0.24
- metabolite measurement · score 0.10
- isolated congenital hypogonadotropic hypogonadism · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q4V9L6-F1 | alphafold | PREDICTED | 58.47 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q4V9L6.
Amino-acid sequence (283 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM119?
The strongest Open Targets associations for TMEM119 are heel bone mineral density, intraocular pressure measurement, refractive error measurement, blood phosphate measurement and P-selectin glycoprotein ligand 1 measurement.
How long is the TMEM119 protein?
The Homo sapiens TMEM119 protein (UniProt Q4V9L6) is 283 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q4V9L6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q4V9L6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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