KH homology domain-containing protein 1 (KHDC1)
Homo sapiens — UniProt Q4VXA5
Data last refreshed: (UniProt release unknown)
Key facts
KH homology domain-containing protein 1 (KHDC1) is a protein from Homo sapiens identified by UniProt accession Q4VXA5, 237 residues long. MolForge cross-references it against 0 known binders and 6 disease associations.
- UniProt accession: Q4VXA5; gene symbol KHDC1.
- Organism: Homo sapiens.
- Length: 237 amino acids.
- Top disease associations (Open Targets): neurofibrillary tangles measurement, brucellosis and cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | KH homology domain-containing protein 1 |
|---|---|
| UniProt accession | Q4VXA5 |
| Gene | KHDC1 |
| Organism | Homo sapiens |
| Length | 237 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (6)
Diseases linked to this target (Open Targets).
- neurofibrillary tangles measurement · score 0.25
- brucellosis · score 0.00
- cancer · score 0.00
- Alzheimer disease · score 0.00
- myelodysplastic syndrome · score 0.00
- osteoarthritis · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q4VXA5-F1 | alphafold | PREDICTED | 68.88 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q4VXA5.
Amino-acid sequence (237 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KHDC1?
The strongest Open Targets associations for KHDC1 are neurofibrillary tangles measurement, brucellosis, cancer, Alzheimer disease and myelodysplastic syndrome.
How long is the KHDC1 protein?
The Homo sapiens KHDC1 protein (UniProt Q4VXA5) is 237 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q4VXA5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q4VXA5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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